Have questions? Visit https://www.reddit.com/r/SNPedia

rs4648261

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(G;G) 0 common in complete genomics
Make rs4648261(A;A)
Make rs4648261(A;G)
ReferenceGRCh38 38.1/142
Chromosome1
Position186679872
GenePTGS2
is asnp
is mentioned by
dbSNPrs4648261
ebirs4648261
HLIrs4648261
Exacrs4648261
Varsomers4648261
Maprs4648261
PheGenIrs4648261
hapmaprs4648261
1000 genomesrs4648261
hgdprs4648261
ensemblrs4648261
gopubmedrs4648261
geneviewrs4648261
scholarrs4648261
googlers4648261
pharmgkbrs4648261
gwascentralrs4648261
openSNPrs4648261
23andMers4648261
23andMe allrs4648261
SNP Nexus

SNPshotrs4648261
SNPdbers4648261
MSV3drs4648261
GWAS Ctlgrs4648261
GMAF0.01423
Max Magnitude0
? (A;A) (A;G) (G;G) 28

news rs4648261 was linked with a reduction in colorectal cancer risk of between 40 to 68 percent. Furthermore, characterizing patients by two SNPs in COX2 suggested that only a subset of patients would derive benefit from NSAID use.

The article notes a paper from AE. Coghill, C. Ulrich where a variety of COX2 genes PTGS-1 variants were associated with CRC survival. One, G>A intron 9 (rs1213266), was associated with ~50% lower CRC mortality (HRAA/AG vs. GG:0.48; 95% CI 0.25-0.93). Three variants, including L237M, resulted in significantly elevated CRC mortality risk, with hazard ratios ranging from approximately 1.5-2.0. Two variants in IkappaBKbeta, including R526Q, were significantly associated with CRC survival.


[PMID 19820421] The Effect of Genetic Polymorphisms of Cyclooxygenase 2 on Acute Pancreatitis in Turkey


[PMID 20676755OA-icon.png] Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study


[PMID 21705955] Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility


[PMID 22551325OA-icon.png] No Association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study