rs4648261

minus

Geno	Mag	Summary
(G;G)	0	common in complete genomics

Make rs4648261(A;A)

Make rs4648261(A;G)

Reference

GRCh38 38.1/142

Chromosome

1

Position

186679872

Gene	PACERR, PTGS2

is a	snp
is	mentioned by
dbSNP	rs4648261
dbSNP (classic)	rs4648261
ClinGen	rs4648261
ebi	rs4648261
HLI	rs4648261
Exac	rs4648261
Gnomad	rs4648261
Varsome	rs4648261
LitVar	rs4648261
Map	rs4648261
PheGenI	rs4648261
Biobank	rs4648261
1000 genomes	rs4648261
hgdp	rs4648261
ensembl	rs4648261
geneview	rs4648261
scholar	rs4648261
google	rs4648261
pharmgkb	rs4648261
gwascentral	rs4648261
openSNP	rs4648261
23andMe	rs4648261
SNPshot	rs4648261
SNPdbe	rs4648261
MSV3d	rs4648261
GWAS Ctlg	rs4648261

GMAF

0.01423

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

news rs4648261 was linked with a reduction in colorectal cancer risk of between 40 to 68 percent. Furthermore, characterizing patients by two SNPs in COX2 suggested that only a subset of patients would derive benefit from NSAID use.

The article notes a paper from AE. Coghill, C. Ulrich where a variety of COX2 genes PTGS-1 variants were associated with CRC survival. One, G>A intron 9 (rs1213266), was associated with ~50% lower CRC mortality (HRAA/AG vs. GG:0.48; 95% CI 0.25-0.93). Three variants, including L237M, resulted in significantly elevated CRC mortality risk, with hazard ratios ranging from approximately 1.5-2.0. Two variants in IkappaBKbeta, including R526Q, were significantly associated with CRC survival.

[PMID 19820421] The Effect of Genetic Polymorphisms of Cyclooxygenase 2 on Acute Pancreatitis in Turkey

[PMID 20676755 ] Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study

[PMID 21705955] Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility

[PMID 22551325 ] No Association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study