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rs4775041

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) lowest phosphatidylethanolamine values
(C;G) intermediate phosphatidylethanolamine values
(G;G) highest phosphatidylethanolamine values
ReferenceGRCh38 38.1/141
Chromosome15
Position58382496
GeneLOC102724766
is asnp
is mentioned by
dbSNPrs4775041
ebirs4775041
HLIrs4775041
Exacrs4775041
Varsomers4775041
Maprs4775041
PheGenIrs4775041
hapmaprs4775041
1000 genomesrs4775041
hgdprs4775041
ensemblrs4775041
gopubmedrs4775041
geneviewrs4775041
scholarrs4775041
googlers4775041
pharmgkbrs4775041
gwascentralrs4775041
openSNPrs4775041
23andMers4775041
23andMe allrs4775041
SNP Nexus

SNPshotrs4775041
SNPdbers4775041
MSV3drs4775041
GWAS Ctlgrs4775041
GMAF0.2112
Max Magnitude
? (C;C) (C;G) (G;G) 28
rs4775041 is a SNP located near the LIPC gene. A study of metabolite concentrations in the blood of 284 adult males from Southern Germany determined that several SNPs were associated either directly with a metabolite range or with a ratio of metabolites. The rarer rs4775041(G) allele was associated with increased phosphatidylethanolamine values. 10.1371/journal.pgen.1000282
Rs4775041 322x277.jpg
GWAS snp
PMID [PMID 19043545OA-icon.png]
Trait Serum metabolites
Title Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
Risk Allele
P-val 1E-7
Odds Ratio NR NR
GWAS snp
PMID [PMID 18193043]
Trait HDL cholesterol
Title Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Risk Allele C
P-val 3.0000000000000003E-20
Odds Ratio 1.38 [NR] mg/dl higher



[PMID 18852197OA-icon.png] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.


[PMID 19041386OA-icon.png] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.


[PMID 19060910OA-icon.png] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.


[PMID 19060911OA-icon.png] Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.


[PMID 19148283OA-icon.png] Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.


[PMID 19299407OA-icon.png] Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.


[PMID 19435741OA-icon.png] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.


[PMID 19656773OA-icon.png] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.


[PMID 19734193OA-icon.png] Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population.


[PMID 20339536OA-icon.png] Genome-wide association of lipid-lowering response to statins in combined study populations.


GET Evidence
rs4775041
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.179688
summary



[PMID 23150898OA-icon.png] Evaluation of seven common lipid associated loci in a large Indian sib pair study