, a SNP in the OR7DR
olfactory receptor gene, is associated with how individuals perceive the smell
of a testosterone-derived steroid, androstenone. This SNP is also known as T133M as it causes a change at amino acid 133 of the OR7D4
protein from threonine to methionine.
In the orientation reported for this SNP in dbSNP, most individuals (~75%) are homozygous for rs5020278(G), and perceive this steroid as smelling either strongly sweaty or like urine. Individuals with one or two copies of rs5020278(A) perceive the smell to be both weaker, and more sweet, with some likening it to vanilla or honey.[PMID 17873857]
|| not reviewed
|| Insufficiently evaluated not reviewed