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rs6136

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 common
(A;C) None
(C;C) None
(T;T) 0
ReferenceGRCh38 38.1/142
Chromosome1
Position169594713
GeneSELP
is asnp
is mentioned by
dbSNPrs6136
ebirs6136
HLIrs6136
Exacrs6136
Varsomers6136
Maprs6136
PheGenIrs6136
hapmaprs6136
1000 genomesrs6136
hgdprs6136
ensemblrs6136
gopubmedrs6136
geneviewrs6136
scholarrs6136
googlers6136
pharmgkbrs6136
gwascentralrs6136
openSNPrs6136
23andMers6136
23andMe allrs6136
SNP Nexus

SNPshotrs6136
SNPdbers6136
MSV3drs6136
GWAS Ctlgrs6136
GMAF0.04408
Max Magnitude0
? (A;A) (A;C) (C;C) 28
[PMID 17944986] cardiovascular risk
GWAS snp
PMID [PMID 20167578OA-icon.png]
Trait Soluble levels of adhesion molecules
Title Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels
Risk Allele T
P-val 4E-61
Odds Ratio 22.60 [19.86-25.34] % increase
OMIM173610
Desc
Variant0001
Relatedalso
[PMID 22473907OA-icon.png] P-selectin genotype is associated with the development of cancer cachexia


ClinVar
Risk rs6136(C;C)
Alt rs6136(C;C)
Reference rs6136(A;A)
Significance Non-pathogenic
Disease SELECTIN P POLYMORPHISM
Variation info
Gene SELP
CLNDBN SELECTIN P POLYMORPHISM
Reversed 1
HGVS NC_000001.10:g.169563951T>G
CLNSRC OMIM Allelic Variant
CLNACC RCV000014482.2,



[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.


[PMID 19404301OA-icon.png] Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE.


GET Evidence
SELP-T756P
aa_change Thr756Pro
aa_change_short T756P
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.0758505
summary



[PMID 24504449] SELP genetic polymorphisms may contribute to the pathogenesis of coronary heart disease and myocardial infarction: a meta-analysis


[PMID 25147926OA-icon.png] Cellular Adhesion Gene SELP Is Associated with Rheumatoid Arthritis and Displays Differential Allelic Expression