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rs6413432

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) CYP2E1_marker9 homozygote
(A;T) carrier of one CYP2E1_marker9 allele
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome10
Position133535040
GeneCYP2E1
is asnp
is mentioned by
dbSNPrs6413432
ebirs6413432
HLIrs6413432
Exacrs6413432
Varsomers6413432
Maprs6413432
PheGenIrs6413432
hapmaprs6413432
1000 genomesrs6413432
hgdprs6413432
ensemblrs6413432
gopubmedrs6413432
geneviewrs6413432
scholarrs6413432
googlers6413432
pharmgkbrs6413432
gwascentralrs6413432
openSNPrs6413432
23andMers6413432
23andMe allrs6413432
SNP Nexus

SNPshotrs6413432
SNPdbers6413432
MSV3drs6413432
GWAS Ctlgrs6413432
GMAF0.1547
Max Magnitude
rs6413432 is a SNP in the CYP2E1 gene.

The rs6413432(A) allele defines the CYP2E1_marker9 variant, as used in the 2008 study determining the 16 most common CYP2E1 haplotypes world-wide.(see CYP2E1 for details)

[PMID 20663217OA-icon.png] Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China

OMIM124040
DescCYTOCHROME P450, SUBFAMILY IIE; CYP2E1
Variant
Relatedalso
OMIM124040
Desc
Variant0002
Relatedalso
[PMID 17116718OA-icon.png] Dietary phytoestrogen intake is associated with reduced colorectal cancer risk.

[PMID 17380320] Genotype and allele frequencies of polymorphic CYP2E1 in the Turkish population.

[PMID 18547414OA-icon.png] Genotyping panel for assessing response to cancer chemotherapy.

[PMID 18663376OA-icon.png] Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene.

[PMID 18990750OA-icon.png] Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.

[PMID 20082485OA-icon.png] Genetic variants involved in gallstone formation and capsaicin metabolism, and the risk of gallbladder cancer in Chilean women.

[PMID 24288753] CYP2E1 Gene Promoter Polymorphism -1293G>C Increases the Risk of Essential Hypertension in Men with Alcohol Abuse [PMID 22560290] A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain.


[PMID 23130019OA-icon.png] Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: comparison with caucasian and asian populations.

ClinVar
Risk rs6413432(A;A)
Alt rs6413432(A;A)
Reference rs6413432(T;T)
Significance Other
Disease CYP2E1*6 ALLELE
Variation info
Gene CYP2E1
CLNDBN CYP2E1*6 ALLELE
Reversed 0
HGVS NC_000010.10:g.135348544T>A
CLNSRC OMIM Allelic Variant
CLNACC RCV000018384.27,


[PMID 26925658] Association of CYP2E1, STK15 and XRCC1 Polymorphisms with Risk of Breast Cancer in Malaysian Women.