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rs643627

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(T;C)
Make rs643627(A;A)
Make rs643627(A;G)
Make rs643627(G;G)
ReferenceGRCh38 38.1/141
Chromosome13
Position46854476
GeneHTR2A, HTR2A-AS1
is asnp
is mentioned by
dbSNPrs643627
ebirs643627
HLIrs643627
Exacrs643627
Varsomers643627
Maprs643627
PheGenIrs643627
hapmaprs643627
1000 genomesrs643627
hgdprs643627
ensemblrs643627
gopubmedrs643627
geneviewrs643627
scholarrs643627
googlers643627
pharmgkbrs643627
gwascentralrs643627
openSNPrs643627
23andMers643627
23andMe allrs643627
SNP Nexus

SNPshotrs643627
SNPdbers643627
MSV3drs643627
GWAS Ctlgrs643627
GMAF0.326
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 16814396] Three (rs643627-rs594242-rs6311: A-C-T), two (rs594242-rs6311: C-T) and a single functional (rs6311: T) marker were protective against suicidal behavior.

The complementary makers (rs594242-rs6311: G-C and rs6311: C) were associated with increased risk for non-violent and impulsive suicidal behavior. Furthermore, CC-homozygotes for the functional SNP rs6311 reported more anger- and aggression-related behavior.


[PMID 20827275] Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects

Genetic evaluation of the serotonergic system in chronic fatigue syndrome.[PMID 18079067] Found that this is in linkage disequilibrium with rs655888.


[PMID 17590256] 5-HT2A SNPs and the Temperament and Character Inventory.


[PMID 26544898] The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment - a European multicentre study