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rs6478108

From SNPedia

Orientationplus
Stabilizedplus
Make rs6478108(C;C)
Make rs6478108(C;T)
Make rs6478108(T;T)
ReferenceGRCh38 38.1/141
Chromosome9
Position114796423
GeneTNFSF15
is asnp
is mentioned by
dbSNPrs6478108
ebirs6478108
HLIrs6478108
Exacrs6478108
Varsomers6478108
Maprs6478108
PheGenIrs6478108
hapmaprs6478108
1000 genomesrs6478108
hgdprs6478108
ensemblrs6478108
gopubmedrs6478108
geneviewrs6478108
scholarrs6478108
googlers6478108
pharmgkbrs6478108
gwascentralrs6478108
openSNPrs6478108
23andMers6478108
23andMe allrs6478108
SNP Nexus

SNPshotrs6478108
SNPdbers6478108
MSV3drs6478108
GWAS Ctlgrs6478108
GMAF0.3072
Max Magnitude
? (C;C) (C;T) (T;T) 28
Associated with increased risk for Crohn's disease in a study of 380 Korean patients.[PMID 18422820]

This SNP is associated with greater susceptibility to leprosy in Asians, according to the 23andMe blog. The risk allele is T, and the odds ratio is 1.37.

The TNFSF15 gene encodes a cytokine protein in the tumor necrosis factor (TNF) family.

OMIM612259
DescINFLAMMATORY BOWEL DISEASE 16; IBD16
Variant
Relatedalso
GWAS snp
PMID [PMID 20018961]
Trait Leprosy
Title Genomewide Association Study of Leprosy
Risk Allele A
P-val 3E-21
Odds Ratio 1.37 [1.28-1.46]

[PMID 17663424OA-icon.png] TNFSF15 is an ethnic-specific IBD gene.

[PMID 18758464OA-icon.png] Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

[PMID 19174806] TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort.

[PMID 19262684OA-icon.png] IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.

[PMID 19543369OA-icon.png] Comprehensive linkage and association analyses identify haplotype, near to the TNFSF15 gene, significantly associated with spondyloarthritis.

[PMID 22684480] Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFalpha


GET Evidence
rs6478108
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.757812
summary



Leprosy Susceptibility


[PMID 24269700] Genetic risk and protective factors of TNFSF15 gene variants detected using single nucleotide polymorphisms in Hungarians with psoriasis and psoriatic arthritis


[PMID 25028192] Associations between TNFSF15 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: A meta-analysis


[PMID 26398853] Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans


[PMID 25501099OA-icon.png] Protective association of tumor necrosis factor superfamily 15 (TNFSF15) polymorphic haplotype with Ulcerative Colitis and Crohn's disease in an Indian population