Have questions? Visit https://www.reddit.com/r/SNPedia

rs689

From SNPedia

Orientationminus
Stabilizedminus
Make rs689(A;A)
Make rs689(A;T)
Make rs689(T;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position2160994
GeneINS, INS-IGF2
is asnp
is mentioned by
dbSNPrs689
ebirs689
HLIrs689
Exacrs689
Varsomers689
Maprs689
PheGenIrs689
hapmaprs689
1000 genomesrs689
hgdprs689
ensemblrs689
gopubmedrs689
geneviewrs689
scholarrs689
googlers689
pharmgkbrs689
gwascentralrs689
openSNPrs689
23andMers689
23andMe allrs689
SNP Nexus

SNPshotrs689
SNPdbers689
MSV3drs689
GWAS Ctlgrs689
GMAF0.3352
Max Magnitude
A strong association between rs689, a SNP within the insulin INS gene, has been reported with type-1 diabetes [PMID 15220214]

Several studies (including [PMID 17554300OA-icon.png]) have mentioned replicating this result, although without mentioning specific risk odds.


[PMID 19956106OA-icon.png] Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families

GWAS snp
PMID [PMID 21829393OA-icon.png]
Trait
Title Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
Risk Allele
P-val 0
Odds Ratio None [2.04-2.63]

[PMID 16595598] The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults.

[PMID 17334650OA-icon.png] A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.

[PMID 17554260OA-icon.png] Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

[PMID 17606874OA-icon.png] Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes.

[PMID 17667841] Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels.

[PMID 17683561OA-icon.png] The TCF7L2 locus and type 1 diabetes.

[PMID 17700581] Association between small for gestational age and paternally inherited 5' insulin haplotypes.

[PMID 18085551] Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease.

[PMID 18252225OA-icon.png] On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.

[PMID 18292987OA-icon.png] Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.

[PMID 18310307] Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.

[PMID 18375961OA-icon.png] Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China.

[PMID 18556337OA-icon.png] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

[PMID 18940880] Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese.

[PMID 19020323OA-icon.png] Genotype score in addition to common risk factors for prediction of type 2 diabetes.

[PMID 19073967OA-icon.png] Shared and distinct genetic variants in type 1 diabetes and celiac disease.

[PMID 19168599OA-icon.png] Type 1 diabetes in the BB rat: a polygenic disease.

[PMID 19188433OA-icon.png] Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?

[PMID 19434426OA-icon.png] Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth.

[PMID 19956109OA-icon.png] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

[PMID 20144318OA-icon.png] A strategy for analyzing gene-nutrient interactions in type 2 diabetes.

[PMID 20628762OA-icon.png] Allele-specific recognition of the 3' splice site of INS intron 1.

[PMID 21278902OA-icon.png] Genetic risk profiling for prediction of type 2 diabetes.

[PMID 22511809] Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.


[PMID 23721563] Associations of polymorphisms in non-HLA loci with autoantibodies at the diagnosis of type 1 diabetes: INS and IKZF4 associate with insulin autoantibodies


[PMID 24275212] The role of tyrosine hydroxylase gene variants in suicide attempt in schizophrenia


[PMID 23835325OA-icon.png] Patterns of beta-cell autoantibody appearance and genetic associations during the first years of life.


[PMID 26074154] Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease.