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rs713041

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;T) 1.3x increased risk of death if diagnosed with breast cancer
(T;T) >1.3x increased risk of death if diagnosed with breast cancer
ReferenceGRCh38 38.1/141
Chromosome19
Position1106616
GeneGPX4
is asnp
is mentioned by
dbSNPrs713041
ebirs713041
HLIrs713041
Exacrs713041
Varsomers713041
Maprs713041
PheGenIrs713041
hapmaprs713041
1000 genomesrs713041
hgdprs713041
ensemblrs713041
gopubmedrs713041
geneviewrs713041
scholarrs713041
googlers713041
pharmgkbrs713041
gwascentralrs713041
openSNPrs713041
23andMers713041
23andMe allrs713041
SNP Nexus

SNPshotrs713041
SNPdbers713041
MSV3drs713041
GWAS Ctlgrs713041
GMAF0.4036
Max Magnitude0
? (C;C) (C;T) (T;T) 28

Two SNPs associated with the antioxidant GPX4 gene, rs713041 and rs757229, are both somewhat correlated (r2=0.61) and are associated with all-cause mortality in breast cancer.

The rs713041(T) allele is associated with an increased risk of death following breast cancer diagnosis, with a hazard ratio of 1.27 per rare allele (CI: 1.13-11.43, p=0.0041).[PMID 17634480]


[PMID 20378690] Genetic variants in selenoprotein genes increase risk of colorectal cancer


[PMID 21733339] SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease


[PMID 20003265OA-icon.png] Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast.


[PMID 20852007] Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men.


[PMID 21459128OA-icon.png] A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells.


[PMID 22139612OA-icon.png] Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand.


[PMID 24499375] Association of Oxidative Stress Related Genes with Idiopathic Recurrent Miscarriage


[PMID 26081749] Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russians


[PMID 26446998OA-icon.png] Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1