Rs713041
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs713041 |
| hapmap | rs713041 |
| hgdp | rs713041 |
| ensembl | rs713041 |
| gopubmed | rs713041 |
| scholar | rs713041 |
| rs713041 | |
| pharmgkb | rs713041 |
| hgvbaseg2p | rs713041 |
| medrefsnp | rs713041 |
| 23andMe | rs713041 |
| SNP Nexus |
| Gene | GPX4 |
| Chromosome | 19 |
| Orientation | plus |
| Position | 1057614 |
| Genotype | Effect |
|---|---|
| rs713041(C;C) | normal |
| rs713041(C;T) | 1.3x increased risk of death if diagnosed with breast cancer |
| rs713041(T;T) | >1.3x increased risk of death if diagnosed with breast cancer |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs713041(C;C) | 00 | normal |
| Rs713041(C;T) | 1.3x increased risk of death if diagnosed with breast cancer | |
| Rs713041(T;T) | >1.3x increased risk of death if diagnosed with breast cancer |
Two SNPs associated with the antioxidant GPX4 gene, rs713041 and rs757229, are both somewhat correlated (r2=0.61) and are associated with all-cause mortality in breast cancer.
The rs713041(T) allele is associated with an increased risk of death following breast cancer diagnosis, with a hazard ratio of 1.27 per rare allele (CI: 1.13-11.43, p=0.0041).[PMID 17634480]
| ? | (C;C) (C;T) (T;T) |
|---|---|
|
| |
