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rs7171755

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.1 very slight descrease in cortical thickness and IQ; see full description
(A;G) 1.1 very slight decrease in cortical thickness and IQ; see full text
(G;G) 1 common/normal
ReferenceGRCh38 38.1/141
Chromosome15
Position73558239
GeneC15orf60
is asnp
is mentioned by
dbSNPrs7171755
ebirs7171755
HLIrs7171755
Exacrs7171755
Varsomers7171755
Maprs7171755
PheGenIrs7171755
hapmaprs7171755
1000 genomesrs7171755
hgdprs7171755
ensemblrs7171755
gopubmedrs7171755
geneviewrs7171755
scholarrs7171755
googlers7171755
pharmgkbrs7171755
gwascentralrs7171755
openSNPrs7171755
23andMers7171755
23andMe allrs7171755
SNP Nexus

SNPshotrs7171755
SNPdbers7171755
MSV3drs7171755
GWAS Ctlgrs7171755
GMAF0.4853
Max Magnitude1.1
? (A;A) (A;G) (G;G) 28
rs7171755 is a SNP near the synaptic cell adhesion glycoprotein-encoding NPTN gene.

A study of ~1,500 adolescents determined that the rs7171755(A) allele is associated with a slightly thinner left hemisphere cortex and also a slight decrease in verbal and nonverbal intelligence (IQ). The differences were really quite slight; each copy of the risk allele decreased cortical thickness by 0.7%, and decreased verbal and nonverbal IQ by 1.8 and 1.4 points, respectively. This study awaits independent replication. Also, note that eight SNPs in the NPTN locus were reported as jointly showing significant association with cortical thickness in addition to rs7171755: rs7176637, rs11854138, rs8028749, rs12185108, rs1564492, rs899981, rs7178269 and rs4075802.10.1038/mp.2013.197