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rs7305115

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) Individuals showed a significantly lower risk of suicide behavior than those with the A/G or G/G genotype
(A;G) risk of suicide behavior
(G;G) risk of suicide behavior
ReferenceGRCh38 38.1/141
Chromosome12
Position71979082
GeneTPH2
is asnp
is mentioned by
dbSNPrs7305115
ebirs7305115
HLIrs7305115
Exacrs7305115
Varsomers7305115
Maprs7305115
PheGenIrs7305115
hapmaprs7305115
1000 genomesrs7305115
hgdprs7305115
ensemblrs7305115
gopubmedrs7305115
geneviewrs7305115
scholarrs7305115
googlers7305115
pharmgkbrs7305115
gwascentralrs7305115
openSNPrs7305115
23andMers7305115
23andMe allrs7305115
SNP Nexus

SNPshotrs7305115
SNPdbers7305115
MSV3drs7305115
GWAS Ctlgrs7305115
GMAF0.4734
Max Magnitude
? (A;A) (A;G) (G;G) 28

[PMID 17011525] Effect of rs7305115 on susceptibility to suicide.


[PMID 19763617] Involvement of tryptophan hydroxylase 2 (TPH2) gene polymorphisms in susceptibility to coronary artery lesions in Korean children with Kawasaki disease



[PMID 20738857OA-icon.png] Effect of Tryptophan Hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression


[PMID 21620479] Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population


[PMID 21969281] Influence of birth weight on internalizing traits modulated by serotonergic genes


[PMID 17649681] [A case-control study on the risk factors for attempted suicide in patients with major depression].


[PMID 18439448OA-icon.png] Stress, genes and the biology of suicidal behavior.


[PMID 18698231OA-icon.png] Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.


[PMID 19693267OA-icon.png] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.


[PMID 20126463OA-icon.png] Alternative splicing and extensive RNA editing of human TPH2 transcripts.


[PMID 20403506OA-icon.png] Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study.


[PMID 20938755] Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 21937687] Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.


GET Evidence
rs7305115
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.582264
summary



[PMID 22655589] Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.


[PMID 23628433] Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.


[PMID 25214390] Interaction among childhood trauma and functional polymorphisms in the serotonin pathway moderate the risk of depressive disorders


[PMID 26028568] Association analysis of TPH-1 and TPH-2 genes with suicidal behavior in patients with attempted suicide in Mexican population


[PMID 26057341] Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population


[PMID 26232682] Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms