rs7646054
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | normal |
| (A;G) | increased osteoporosis risk | |
| (G;G) | increased osteoporosis risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 3 |
| Position | 56775600 |
| Gene | ARHGEF3 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7646054 |
| dbSNP (classic) | rs7646054 |
| ClinGen | rs7646054 |
| ebi | rs7646054 |
| HLI | rs7646054 |
| Exac | rs7646054 |
| Gnomad | rs7646054 |
| Varsome | rs7646054 |
| LitVar | rs7646054 |
| Map | rs7646054 |
| PheGenI | rs7646054 |
| Biobank | rs7646054 |
| 1000 genomes | rs7646054 |
| hgdp | rs7646054 |
| ensembl | rs7646054 |
| geneview | rs7646054 |
| scholar | rs7646054 |
| rs7646054 | |
| pharmgkb | rs7646054 |
| gwascentral | rs7646054 |
| openSNP | rs7646054 |
| 23andMe | rs7646054 |
| SNPshot | rs7646054 |
| SNPdbe | rs7646054 |
| MSV3d | rs7646054 |
| GWAS Ctlg | rs7646054 |
| GMAF | 0.3122 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs7646054 is a SNP in the ARHGEF3 gene.
A study of 769 Australian female siblings found that the rs7646054(G) allele was significantly associated with lower bone mineral density (BMD) and thus osteoporosis in an age-related manner. Significant associations with hip and spine BMD were confirmed (p = 0.003-0.038), as well as an association with fracture rate (p = 0.02).
[PMID 19727905
] Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women.
