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rs7646054

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) increased osteoporosis risk
(G;G) increased osteoporosis risk
ReferenceGRCh38 38.1/141
Chromosome3
Position56775600
GeneARHGEF3
is asnp
is mentioned by
dbSNPrs7646054
ebirs7646054
HLIrs7646054
Exacrs7646054
Varsomers7646054
Maprs7646054
PheGenIrs7646054
hapmaprs7646054
1000 genomesrs7646054
hgdprs7646054
ensemblrs7646054
gopubmedrs7646054
geneviewrs7646054
scholarrs7646054
googlers7646054
pharmgkbrs7646054
gwascentralrs7646054
openSNPrs7646054
23andMers7646054
23andMe allrs7646054
SNP Nexus

SNPshotrs7646054
SNPdbers7646054
MSV3drs7646054
GWAS Ctlgrs7646054
GMAF0.3122
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs7646054 is a SNP in the ARHGEF3 gene.

A study of 769 Australian female siblings found that the rs7646054(G) allele was significantly associated with lower bone mineral density (BMD) and thus osteoporosis in an age-related manner. Significant associations with hip and spine BMD were confirmed (p = 0.003-0.038), as well as an association with fracture rate (p = 0.02).



[PMID 19727905OA-icon.png] Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women.


GET Evidence
rs7646054
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.695312
summary