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rs7776725

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 weaker bones
(T;T) 2 stronger bones
Make rs7776725(C;T)
ReferenceGRCh38 38.1/141
Chromosome7
Position121393067
GeneFAM3C
is asnp
is mentioned by
dbSNPrs7776725
ebirs7776725
HLIrs7776725
Exacrs7776725
Varsomers7776725
Maprs7776725
PheGenIrs7776725
hapmaprs7776725
1000 genomesrs7776725
hgdprs7776725
ensemblrs7776725
gopubmedrs7776725
geneviewrs7776725
scholarrs7776725
googlers7776725
pharmgkbrs7776725
gwascentralrs7776725
openSNPrs7776725
23andMers7776725
23andMe allrs7776725
SNP Nexus

SNPshotrs7776725
SNPdbers7776725
MSV3drs7776725
GWAS Ctlgrs7776725
GMAF0.2489
Max Magnitude2
? (C;C) (C;T) (T;T) 28
10.1038/ng.357 Korean bone mineral density rs7776725 and rs1721400
GWAS snp
PMID [PMID 19396169]
Trait Biomedical quantitative traits
Title A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
Risk Allele C
P-val 0.000002
Odds Ratio NR NR


[PMID 22792071OA-icon.png] WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk


[PMID 21655950] Heterogeneous genetic associations of nucleotide sequence variants with bone mineral density by gender.


[PMID 22159821OA-icon.png] A follow-up association study of two genetic variants for bone mineral density variation in Caucasians.


GET Evidence
rs7776725
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.34375
summary



GWAS snp
PMID [PMID 24945404OA-icon.png]
Trait Bone mineral density (paediatric, total body less head)
Title Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
Risk Allele C
P-val 6E-20
Odds Ratio .16 [0.13-0.19] unit increase