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rs806380

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 Normal genotype. slightly higher odds of cannabis dependence
(A;G)
(G;G) 2.1 uncommon. lowest odds of cannabis dependence
ReferenceGRCh38 38.1/141
Chromosome6
Position88154934
GeneCNR1
is asnp
is mentioned by
dbSNPrs806380
ebirs806380
HLIrs806380
Exacrs806380
Varsomers806380
Maprs806380
PheGenIrs806380
hapmaprs806380
1000 genomesrs806380
hgdprs806380
ensemblrs806380
gopubmedrs806380
geneviewrs806380
scholarrs806380
googlers806380
pharmgkbrs806380
gwascentralrs806380
openSNPrs806380
23andMers806380
23andMe allrs806380
SNP Nexus

SNPshotrs806380
SNPdbers806380
MSV3drs806380
GWAS Ctlgrs806380
GMAF0.2185
Max Magnitude2.1
? (A;A) (A;G) (G;G) 28

This snp, located in intron 2 of the central cannabinoid receptor CNR1 gene, has been linked to cannabis dependence. [PMID 16917946OA-icon.png]

The (G) allele is reported to have a protective effect, and is a defining part of a haplotype that is associated with lower odds of developing cannabis dependence. The (A) allele is more common in all populations studied.


[PMID 19443135OA-icon.png] The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults


[PMID 18606954OA-icon.png] Cannabinoid receptor 1 gene association with nicotine dependence.


[PMID 19016476OA-icon.png] Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.


[PMID 19052543OA-icon.png] Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.


[PMID 19335651OA-icon.png] Candidate genes for cannabis use disorders: findings, challenges and directions.

[PMID 21714860OA-icon.png] Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces. (G;G) is also associated with the longest gaze duration for happy faces.