rs806380
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2 | Normal genotype. slightly higher odds of cannabis dependence |
| (A;G) | ||
| (G;G) | 2.1 | uncommon. lowest odds of cannabis dependence |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 88154934 |
| Gene | CNR1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs806380 |
| dbSNP (classic) | rs806380 |
| ClinGen | rs806380 |
| ebi | rs806380 |
| HLI | rs806380 |
| Exac | rs806380 |
| Gnomad | rs806380 |
| Varsome | rs806380 |
| LitVar | rs806380 |
| Map | rs806380 |
| PheGenI | rs806380 |
| Biobank | rs806380 |
| 1000 genomes | rs806380 |
| hgdp | rs806380 |
| ensembl | rs806380 |
| geneview | rs806380 |
| scholar | rs806380 |
| rs806380 | |
| pharmgkb | rs806380 |
| gwascentral | rs806380 |
| openSNP | rs806380 |
| 23andMe | rs806380 |
| SNPshot | rs806380 |
| SNPdbe | rs806380 |
| MSV3d | rs806380 |
| GWAS Ctlg | rs806380 |
| GMAF | 0.2185 |
| Max Magnitude | 2.1 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
This snp, located in intron 2 of the central cannabinoid receptor CNR1 gene, has been linked to cannabis dependence. [PMID 16917946
]
The (G) allele is reported to have a protective effect, and is a defining part of a haplotype that is associated with lower odds of developing cannabis dependence. The (A) allele is more common in all populations studied.
[PMID 19443135] The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults
[PMID 18606954] Cannabinoid receptor 1 gene association with nicotine dependence.
[PMID 19016476] Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.
[PMID 19052543] Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.
[PMID 19335651] Candidate genes for cannabis use disorders: findings, challenges and directions.
[PMID 21714860] Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces. (G;G) is also associated with the longest gaze duration for happy faces.
[PMID 28349993] Cannabinoid Receptor Type 1 and mu-Opioid Receptor Polymorphisms Are Associated With Cyclic Vomiting Syndrome.
