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rs8069176

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) normal
(G;G) if 4 years old or younger, ~3x increased asthma risk if exposed to smoke
ReferenceGRCh38 38.1/141
Chromosome17
Position39900944
is asnp
is mentioned by
dbSNPrs8069176
ebirs8069176
HLIrs8069176
Exacrs8069176
Varsomers8069176
Maprs8069176
PheGenIrs8069176
hapmaprs8069176
1000 genomesrs8069176
hgdprs8069176
ensemblrs8069176
gopubmedrs8069176
geneviewrs8069176
scholarrs8069176
googlers8069176
pharmgkbrs8069176
gwascentralrs8069176
openSNPrs8069176
23andMers8069176
23andMe allrs8069176
SNP Nexus

SNPshotrs8069176
SNPdbers8069176
MSV3drs8069176
GWAS Ctlgrs8069176
GMAF0.3852
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs8069176 is one of several SNPs from a region on chromosome 17q21 that has been linked to risk for asthma.

A total of 651 French patients with asthma, from among 1,621 subjects in 388 families, were analyzed for SNPs in the (17q21) region. An association was found between this SNP and early-onset asthma (but not with later onset asthma) which was significant after correction at p < 0.001. Upon further study, this association was seen primarily only in children exposed to tobacco smoke. The odds ratio was 2.9, based on the most likely assumption that this risk is associated only with the recessive homozygous state (and not the heterozygous state, which is still possible). [PMID 18923164]


OMIM611403
Desc
Variant
Relatedalso


[PMID 22370936] Genetic variants on 17q21 are associated with asthma in a Han Chinese population


GET Evidence
rs8069176
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.375
summary



GWAS snp
PMID [PMID 24315451OA-icon.png]
Trait Fractional exhaled nitric oxide (childhood)
Title Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.
Risk Allele A
P-val 2E-8
Odds Ratio .07 [0.042-0.09] unit decrease