Have questions? Visit https://www.reddit.com/r/SNPedia

rs8177374

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common on affy axiom data
(T;T) 3.5 resistance to several diseases
Make rs8177374(C;T)
ReferenceGRCh38 38.1/141
Chromosome11
Position126292948
GeneTIRAP
is asnp
is mentioned by
dbSNPrs8177374
ebirs8177374
HLIrs8177374
Exacrs8177374
Varsomers8177374
Maprs8177374
PheGenIrs8177374
hapmaprs8177374
1000 genomesrs8177374
hgdprs8177374
ensemblrs8177374
gopubmedrs8177374
geneviewrs8177374
scholarrs8177374
googlers8177374
pharmgkbrs8177374
gwascentralrs8177374
openSNPrs8177374
23andMers8177374
23andMe allrs8177374
SNP Nexus

SNPshotrs8177374
SNPdbers8177374
MSV3drs8177374
GWAS Ctlgrs8177374
GMAF0.08402
Max Magnitude3.5
? (C;C) (C;T) (T;T) 28

23andMe blog rs8177374(T) less susceptible to infection with malaria, tuberculosis, bacteremia and pneumococcal disease.

[PMID 19509334OA-icon.png] Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

OMIM606252
DescTIR DOMAIN-CONTAINING ADAPTOR PROTEIN; TIRAP
Variant
Relatedalso


OMIM606252
Desc
Variant0001
Relatedalso


ClinVar
Risk rs8177374(T;T)
Alt rs8177374(T;T)
Reference rs8177374(C;C)
Significance Other
Disease Invasive pneumococcal disease Malaria Mycobacterium tuberculosis Bacteremia
Variation info
Gene TIRAP
CLNDBN Invasive pneumococcal disease, protection against Malaria, resistance to Mycobacterium tuberculosis, protection against Bacteremia, resistance to
Reversed 0
HGVS NC_000011.9:g.126162843C>T
CLNSRC OMIM Allelic Variant
CLNACC RCV000004722.2, RCV000004723.2, RCV000004724.2, RCV000023527.2,



[PMID 19543401OA-icon.png] Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.


[PMID 20016852OA-icon.png] Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.


[PMID 20525286OA-icon.png] Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.


[PMID 21274447OA-icon.png] Genetic polymorphisms and posttraumatic complications.


[PMID 21399862] Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.


[PMID 23047423] A TIR domain receptor-associated protein (TIRAP) variant SNP (rs8177374) confers protection against premature birth


GET Evidence
TIRAP-S180L
aa_change Ser180Leu
aa_change_short S180L
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.114798
summary



[PMID 22691414OA-icon.png] Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children


[PMID 24064014] TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behçet's disease patients in two ethnic cohorts


[PMID 23255565OA-icon.png] Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.


[PMID 24067789] The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis