|| 2x increased risk for neuroblastoma
|| possible increased risk for neuroblastoma
|?|| (A;A) (A;C) (C;C) ||28|
SNPs clustered in one region of chromosome 6p22 have been linked to increased risk for the exceedingly rare childhood cancer known as neuroblastoma. A study involving 720 patients determined that rs9295536(A;A) genotypes had increased likelihood of neuroblastoma development (odds ratio 1.93, CI: 1.55 to 2.40, p=8 x 10-8). At-risk homozygotes diagnosed with neuroblastoma had, on average, more malignant clinical presentation, more aggressive disease, and poorer long-term survival.[PMID 18463370]
For more information on this cluster of SNPs, see rs6939340.
] Common variations in BARD1 influence susceptibility to high-risk neuroblastoma.
|| [PMID 22941191]
|| Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
| Risk Allele
| Odds Ratio
|| 1.36 [NR]