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rs9357271

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) <0.63x risk for restless legs
(C;T) 0.63x risk for restless legs
(T;T) 1 Normal risk of developing restless legs syndrome
ReferenceGRCh38 38.1/141
Chromosome6
Position38398097
GeneBTBD9
is asnp
is mentioned by
dbSNPrs9357271
ebirs9357271
HLIrs9357271
Exacrs9357271
Varsomers9357271
Maprs9357271
PheGenIrs9357271
hapmaprs9357271
1000 genomesrs9357271
hgdprs9357271
ensemblrs9357271
gopubmedrs9357271
geneviewrs9357271
scholarrs9357271
googlers9357271
pharmgkbrs9357271
gwascentralrs9357271
openSNPrs9357271
23andMers9357271
23andMe allrs9357271
SNP Nexus

SNPshotrs9357271
SNPdbers9357271
MSV3drs9357271
GWAS Ctlgrs9357271
GMAF0.4734
Max Magnitude1
? (C;C) (C;T) (T;T) 28
rs9357271, a SNP located in the BTBD9 gene region, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.63 (CI: 0.52-0.75) for the (C) minor allele. [PMID 17637780]


This SNP may also be associated with Tourette syndrome (TS), particularly TS without obsessive-compulsive disorder, based on a study of ~600 patients.[PMID 19822783]

Neighborrs9296249
Distance32
OMIM611185
DescRESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 6
Variant
Relatedalso


GWAS snp
PMID [PMID 21779176OA-icon.png]
Trait
Title Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
Risk Allele T
P-val 8E-22
Odds Ratio 1.4700 [1.35-1.47]


GET Evidence
rs9357271
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.46875
summary



[PMID 23361623] The BTBD9 gene may be associated with antipsychotic-induced restless legs syndrome in schizophrenia


[PMID 22914617] Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.


[PMID 26597663] Genetic factors influencing ferritin levels in 14,126 blood donors: results from the Danish Blood Donor Study