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rs9402571

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 1.8 0.85x decreased risk for type-2 diabetes
(G;T) 1.4 slightly decreased risk for type-2 diabetes
(T;T) normal
ReferenceGRCh38 38.1/141
Chromosome6
Position134167822
GeneSGK1
is asnp
is mentioned by
dbSNPrs9402571
ebirs9402571
HLIrs9402571
Exacrs9402571
Varsomers9402571
Maprs9402571
PheGenIrs9402571
hapmaprs9402571
1000 genomesrs9402571
hgdprs9402571
ensemblrs9402571
gopubmedrs9402571
geneviewrs9402571
scholarrs9402571
googlers9402571
pharmgkbrs9402571
gwascentralrs9402571
openSNPrs9402571
23andMers9402571
23andMe allrs9402571
SNP Nexus

SNPshotrs9402571
SNPdbers9402571
MSV3drs9402571
GWAS Ctlgrs9402571
GMAF0.2603
Max Magnitude1.8
? (G;G) (G;T) (T;T) 28
rs9402571 is a SNP in the serum/glucocorticoid regulated kinase 1 SGK1 gene.

Three independent European populations were analyzed, with follow up in 3798 non-diabetic and 659 diabetic (type 2) individuals, for associations between SGK1 SNPs and insulin secretion. In lean non-diabetic individuals, rs9402571(G) minor allele carriers had higher (better) insulin response and lower prevalence of type-2 diabetes, with an odds ratio of 0.85 (CI: 0.7-1.0, p = .065, dominant model). [PMID 18985156OA-icon.png]


[PMID 22648267OA-icon.png] Polymorphisms in the serum- and glucocorticoid-inducible kinase 1 gene are associated with blood pressure and renin response to dietary salt intake.