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rs964184

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
(G;G) 2.2 increased risk of hypertriglyceridemia
Make rs964184(C;G)
ReferenceGRCh38 38.1/141
Chromosome11
Position116778201
GeneZPR1
is asnp
is mentioned by
dbSNPrs964184
ebirs964184
HLIrs964184
Exacrs964184
Varsomers964184
Maprs964184
PheGenIrs964184
hapmaprs964184
1000 genomesrs964184
hgdprs964184
ensemblrs964184
gopubmedrs964184
geneviewrs964184
scholarrs964184
googlers964184
pharmgkbrs964184
gwascentralrs964184
openSNPrs964184
23andMers964184
23andMe allrs964184
SNP Nexus

SNPshotrs964184
SNPdbers964184
MSV3drs964184
GWAS Ctlgrs964184
GMAF0.2002
Max Magnitude2.2
? (C;C) (C;G) (G;G) 28
GWAS snp
PMID [PMID 19060906OA-icon.png]
Trait HDL cholesterol
Title Common variants at 30 loci contribute to polygenic dyslipidemia
Risk Allele G
P-val 1E-12
Odds Ratio 0.17 [0.11-0.23] SD decrease


GWAS snp
PMID [PMID 20657596OA-icon.png]
Trait Hypertriglyceridemia
Title Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
Risk Allele G
P-val 5E-24
Odds Ratio 3.28 [2.61-4.14]
GWAS snp
PMID [PMID 20864672OA-icon.png]
Trait
Title Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
Risk Allele G
P-val 2E-11
Odds Ratio 0.03 [0.02-0.04] unit decrease


The rs964184(G;G) genotype is associated with hypertriglyceridemia. [PMID 20657596OA-icon.png]

GWAS snp
PMID [PMID 21378990OA-icon.png]
Trait
Title Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Risk Allele G
P-val 1E-17
Odds Ratio 1.1300 [1.10-1.16]
GWAS snp
PMID [PMID 21729881OA-icon.png]
Trait
Title Genome-wide association study identifies common variants associated with circulating vitamin E levels.
Risk Allele G
P-val 8E-12
Odds Ratio 0.0400 [0.02-0.06] unit increase
GWAS snp
PMID [PMID 22003152OA-icon.png]
Trait
Title Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.
Risk Allele C
P-val 8E-11
Odds Ratio 0.0320 None
GWAS snp
PMID [PMID 20686565OA-icon.png]
Trait
Title Biological, clinical and population relevance of 95 loci for blood lipids.
Risk Allele G
P-val 0
Odds Ratio 16.9500 None


[PMID 22399527OA-icon.png] Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution but No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits


[PMID 21889769] Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia


[PMID 22437554OA-icon.png] Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men.


[PMID 22567092OA-icon.png] MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS

GWAS snp
PMID [PMID 22359512OA-icon.png]
Trait
Title Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
Risk Allele
P-val 2E-10
Odds Ratio 1.0000 None


[PMID 19656773OA-icon.png] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.


[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.


[PMID 20160193OA-icon.png] Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.


[PMID 20339536OA-icon.png] Genome-wide association of lipid-lowering response to statins in combined study populations.


[PMID 20385826OA-icon.png] Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).


GET Evidence
rs964184
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.84375
summary



[PMID 23119086OA-icon.png] Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to Fenofibrate


[PMID 23404648OA-icon.png] An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease

GWAS snp
PMID [PMID 22916037OA-icon.png]
Trait Metabolite levels
Title Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
Risk Allele
P-val 8E-20
Odds Ratio NR NR
GWAS snp
PMID [PMID 23505323OA-icon.png]
Trait Hypertriglyceridemia
Title Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
Risk Allele
P-val 5E-35
Odds Ratio 1.77 [1.67-1.87]
GWAS snp
PMID [PMID 23726366OA-icon.png]
Trait Triglycerides
Title Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations.
Risk Allele G
P-val 4E-33
Odds Ratio .16 [NR] unit increase


[PMID 24623848OA-icon.png] Genetic Variants Reflecting Higher Vitamin E Status in Men Are Associated with Reduced Risk of Prostate Cancer


[PMID 22914552OA-icon.png] APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention: the Pounds Lost Trial.


[PMID 23832694] Common genetic variants associated with lipid profiles in a Chinese pediatric population.

GWAS snp
PMID [PMID 24262325OA-icon.png]
Trait Coronary artery disease or ischemic stroke
Title Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Risk Allele
P-val 2E-5
Odds Ratio NR NR
GWAS snp
PMID [PMID 24097068OA-icon.png]
Trait Cholesterol, total
Title Discovery and refinement of loci associated with lipid levels.
Risk Allele C
P-val 3E-55
Odds Ratio .12 [NR] unit decrease
GWAS snp
PMID [PMID 24816252OA-icon.png]
Trait Blood metabolite levels
Title An atlas of genetic influences on human blood metabolites.
Risk Allele C
P-val 8E-15
Odds Ratio .03 [0.019-0.031] unit decrease
GWAS snp
PMID [PMID 24886709OA-icon.png]
Trait Triglycerides
Title Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
Risk Allele G
P-val 6E-33
Odds Ratio 1.89 [1.69-2.08]


[PMID 24989072] Association between the MLX interacting protein-like, BUD13 homolog and zinc finger protein 259 gene polymorphisms and serum lipid levels


[PMID 26405538OA-icon.png] Association of FURIN and ZPR1 polymorphisms with metabolic syndrome


[PMID 26445370OA-icon.png] Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status - The HUNT Study


[PMID 26885234] Association study of BUD13-ZNF259 gene rs964184 polymorphism and hemorrhagic stroke risk.