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From SNPedia

Geno Mag Summary
(C;C) 0
(G;G) 2.2 increased risk of hypertriglyceridemia
Make rs964184(C;G)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs964184
23andMe allrs964184
SNP Nexus

GWAS Ctlgrs964184
Max Magnitude2.2
? (C;C) (C;G) (G;G) 28
GWAS snp
PMID [PMID 19060906OA-icon.png]
Trait HDL cholesterol
Title Common variants at 30 loci contribute to polygenic dyslipidemia
Risk Allele G
P-val 1E-12
Odds Ratio 0.17 [0.11-0.23] SD decrease

GWAS snp
PMID [PMID 20657596OA-icon.png]
Trait Hypertriglyceridemia
Title Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia
Risk Allele G
P-val 5E-24
Odds Ratio 3.28 [2.61-4.14]
GWAS snp
PMID [PMID 20864672OA-icon.png]
Title Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
Risk Allele G
P-val 2E-11
Odds Ratio 0.03 [0.02-0.04] unit decrease

The rs964184(G;G) genotype is associated with hypertriglyceridemia. [PMID 20657596OA-icon.png]

GWAS snp
PMID [PMID 21378990OA-icon.png]
Title Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Risk Allele G
P-val 1E-17
Odds Ratio 1.1300 [1.10-1.16]
GWAS snp
PMID [PMID 21729881OA-icon.png]
Title Genome-wide association study identifies common variants associated with circulating vitamin E levels.
Risk Allele G
P-val 8E-12
Odds Ratio 0.0400 [0.02-0.06] unit increase
GWAS snp
PMID [PMID 22003152OA-icon.png]
Title Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.
Risk Allele C
P-val 8E-11
Odds Ratio 0.0320 None
GWAS snp
PMID [PMID 20686565OA-icon.png]
Title Biological, clinical and population relevance of 95 loci for blood lipids.
Risk Allele G
P-val 0
Odds Ratio 16.9500 None

[PMID 22399527OA-icon.png] Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution but No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits

[PMID 21889769] Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia

[PMID 22437554OA-icon.png] Genome-Wide Association Study Identifies Three Common Variants Associated with Serologic Response to Vitamin E Supplementation in Men.

[PMID 22567092OA-icon.png] MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS

GWAS snp
PMID [PMID 22359512OA-icon.png]
Title Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
Risk Allele
P-val 2E-10
Odds Ratio 1.0000 None

[PMID 19656773OA-icon.png] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.

[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

[PMID 20160193OA-icon.png] Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.

[PMID 20339536OA-icon.png] Genome-wide association of lipid-lowering response to statins in combined study populations.

[PMID 20385826OA-icon.png] Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).

GET Evidence
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.84375

[PMID 23119086OA-icon.png] Variants Identified in a GWAS Meta-Analysis for Blood Lipids Are Associated with the Lipid Response to Fenofibrate

[PMID 23404648OA-icon.png] An association study between genetic polymorphisms related to lipoprotein-associated phospholipase A(2) and coronary heart disease

GWAS snp
PMID [PMID 22916037OA-icon.png]
Trait Metabolite levels
Title Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
Risk Allele
P-val 8E-20
Odds Ratio NR NR
GWAS snp
PMID [PMID 23505323OA-icon.png]
Trait Hypertriglyceridemia
Title Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
Risk Allele
P-val 5E-35
Odds Ratio 1.77 [1.67-1.87]
GWAS snp
PMID [PMID 23726366OA-icon.png]
Trait Triglycerides
Title Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations.
Risk Allele G
P-val 4E-33
Odds Ratio .16 [NR] unit increase

[PMID 24623848OA-icon.png] Genetic Variants Reflecting Higher Vitamin E Status in Men Are Associated with Reduced Risk of Prostate Cancer

[PMID 22914552OA-icon.png] APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention: the Pounds Lost Trial.

[PMID 23832694] Common genetic variants associated with lipid profiles in a Chinese pediatric population.

GWAS snp
PMID [PMID 24262325OA-icon.png]
Trait Coronary artery disease or ischemic stroke
Title Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Risk Allele
P-val 2E-5
Odds Ratio NR NR
GWAS snp
PMID [PMID 24097068OA-icon.png]
Trait Cholesterol, total
Title Discovery and refinement of loci associated with lipid levels.
Risk Allele C
P-val 3E-55
Odds Ratio .12 [NR] unit decrease
GWAS snp
PMID [PMID 24816252OA-icon.png]
Trait Blood metabolite levels
Title An atlas of genetic influences on human blood metabolites.
Risk Allele C
P-val 8E-15
Odds Ratio .03 [0.019-0.031] unit decrease
GWAS snp
PMID [PMID 24886709OA-icon.png]
Trait Triglycerides
Title Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
Risk Allele G
P-val 6E-33
Odds Ratio 1.89 [1.69-2.08]

[PMID 24989072] Association between the MLX interacting protein-like, BUD13 homolog and zinc finger protein 259 gene polymorphisms and serum lipid levels

[PMID 26405538OA-icon.png] Association of FURIN and ZPR1 polymorphisms with metabolic syndrome

[PMID 26445370OA-icon.png] Genetic Effects on Longitudinal Changes from Healthy to Adverse Weight and Metabolic Status - The HUNT Study

[PMID 26885234] Association study of BUD13-ZNF259 gene rs964184 polymorphism and hemorrhagic stroke risk.