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rs9951307

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) 0 0.10 decreased risk for brain edema after a stroke
(G;G) 0.10 decreased risk for brain edema after a stroke
ReferenceGRCh38 38.1/141
Chromosome18
Position26850565
GeneAQP4
is asnp
is mentioned by
dbSNPrs9951307
ebirs9951307
HLIrs9951307
Exacrs9951307
Varsomers9951307
Maprs9951307
PheGenIrs9951307
hapmaprs9951307
1000 genomesrs9951307
hgdprs9951307
ensemblrs9951307
gopubmedrs9951307
geneviewrs9951307
scholarrs9951307
googlers9951307
pharmgkbrs9951307
gwascentralrs9951307
openSNPrs9951307
23andMers9951307
23andMe allrs9951307
SNP Nexus

SNPshotrs9951307
SNPdbers9951307
MSV3drs9951307
GWAS Ctlgrs9951307
GMAF0.2957
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs9951307is a SNP in the aquaporin-4 (AQP4) gene; the corresponding protein is the main water channel in the brain and is implicated in the development of brain edema after an ischemic stroke.

A study of 41 patients with middle cerebral artery occlusion with and without severe brain edema found that rs9951307 was associated with severe brain edema (dominant model, p=0.01; OR, 0.10, CI: 0.02 to 0.49 for the protective (G) allele).[PMID 18309154]