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rs999737

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common on affy axiom data
Make rs999737(C;T)
Make rs999737(T;T)
ReferenceGRCh38 38.1/141
Chromosome14
Position68567965
GeneRAD51B
is asnp
is mentioned by
dbSNPrs999737
ebirs999737
HLIrs999737
Exacrs999737
Varsomers999737
Maprs999737
PheGenIrs999737
hapmaprs999737
1000 genomesrs999737
hgdprs999737
ensemblrs999737
gopubmedrs999737
geneviewrs999737
scholarrs999737
googlers999737
pharmgkbrs999737
gwascentralrs999737
openSNPrs999737
23andMers999737
23andMe allrs999737
SNP Nexus

SNPshotrs999737
SNPdbers999737
MSV3drs999737
GWAS Ctlgrs999737
GMAF0.1088
Max Magnitude0
? (C;C) (C;T) (T;T) 28
NIH rs999737 is located near an interesting gene, RAD51L1, which is in a pathway previously implicated in breast cancer risk. The protein encoded by this gene interacts directly with those of other genes that are involved in DNA repair and in the exchange of material between strands of DNA.

[PMID 19330030OA-icon.png] A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).


OMIM114480
Desc
Variant
Relatedalso
[PMID 21791674OA-icon.png] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium


[PMID 21852249OA-icon.png] Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: Findings from the Breast Cancer Association Consortium


[PMID 21959381OA-icon.png] Fine mapping of 14q24.1 breast cancer susceptibility locus


[PMID 21593217OA-icon.png] Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers


[PMID 22313133OA-icon.png] Genetic Variants at 14q24.1 and Breast Cancer Susceptibility: a Fine-Mapping Study in Chinese Women common variants at 14q24.1 might not be associated with the risk of breast cancer in the Chinese population. Rs999737 is not a risk allele for Chinese


[PMID 20085711OA-icon.png] Leveraging genetic variability across populations for the identification of causal variants.


[PMID 20146796OA-icon.png] Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.


[PMID 20237344OA-icon.png] Performance of common genetic variants in breast-cancer risk models.


[PMID 21844186OA-icon.png] Common breast cancer susceptibility loci are associated with triple-negative breast cancer.


GET Evidence
rs999737
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.09375
summary



GWAS snp
PMID [PMID 23535729OA-icon.png]
Trait Breast cancer
Title Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Risk Allele C
P-val 3E-19
Odds Ratio 1.09 [1.06-1.11]