rs999737
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common on affy axiom data |
| Make rs999737(C;T) |
| Make rs999737(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 14 |
| Position | 68567965 |
| Gene | RAD51B |
| is a | snp |
| is | mentioned by |
| dbSNP | rs999737 |
| dbSNP (classic) | rs999737 |
| ClinGen | rs999737 |
| ebi | rs999737 |
| HLI | rs999737 |
| Exac | rs999737 |
| Gnomad | rs999737 |
| Varsome | rs999737 |
| LitVar | rs999737 |
| Map | rs999737 |
| PheGenI | rs999737 |
| Biobank | rs999737 |
| 1000 genomes | rs999737 |
| hgdp | rs999737 |
| ensembl | rs999737 |
| geneview | rs999737 |
| scholar | rs999737 |
| rs999737 | |
| pharmgkb | rs999737 |
| gwascentral | rs999737 |
| openSNP | rs999737 |
| 23andMe | rs999737 |
| SNPshot | rs999737 |
| SNPdbe | rs999737 |
| MSV3d | rs999737 |
| GWAS Ctlg | rs999737 |
| GMAF | 0.1088 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
NIH rs999737 is located near an interesting gene, RAD51L1, which is in a pathway previously implicated in breast cancer risk. The protein encoded by this gene interacts directly with those of other genes that are involved in DNA repair and in the exchange of material between strands of DNA.
[PMID 19330030
] A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
[PMID 21791674] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
[PMID 21852249] Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: Findings from the Breast Cancer Association Consortium
[PMID 21959381] Fine mapping of 14q24.1 breast cancer susceptibility locus
[PMID 21593217] Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
[PMID 22313133] Genetic Variants at 14q24.1 and Breast Cancer Susceptibility: a Fine-Mapping Study in Chinese Women
common variants at 14q24.1 might not be associated with the risk of breast cancer in the Chinese population.
Rs999737 is not a risk allele for Chinese
[PMID 20085711] Leveraging genetic variability across populations for the identification of causal variants.
[PMID 20146796] Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.
[PMID 20237344] Performance of common genetic variants in breast-cancer risk models.
[PMID 21844186] Common breast cancer susceptibility loci are associated with triple-negative breast cancer.
| GWAS snp | |
|---|---|
| PMID | [PMID 23535729]
|
| Trait | Breast cancer |
| Title | Large-scale genotyping identifies 41 new loci associated with breast cancer risk. |
| Risk Allele | C |
| P-val | 3E-19 |
| Odds Ratio | 1.09 [1.06-1.11] |
