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SLCO1B1

From SNPedia

is agene
is mentioned by
Full namesolute carrier organic anion transporter family, member 1B1
EntrezGene10599
PheGenI10599
VariationViewer10599
ClinVarSLCO1B1
GeneCardsSLCO1B1
dbSNP10599
SADR10599
HugeNav10599
wikipediaSLCO1B1
googleSLCO1B1
gopubmedSLCO1B1
EVSSLCO1B1
HEFalMpSLCO1B1
MyGene2SLCO1B1
23andMeSLCO1B1
UniProtQ9Y6L6
EnsemblENSG00000134538
OMIM604843
# SNPs26
 Max MagnitudeChromosome positionSummary
rs1084175321,168,436
rs1104581821,176,827
rs11045819021,176,879
rs11045849021,196,677
rs1104587921,229,685
rs1231726821,199,607
rs1258271721,143,872
rs1282970421,235,687
rs156437021,182,256
rs183501729021,196,975
rs187139521,199,381
rs229107521,178,691
rs230628321,176,804
rs4149013021,129,476
rs414901421,130,019
rs4149015021,130,388
rs414901821,138,627
rs41490563.221,178,615
rs414908021,224,625
rs414908121,225,087
rs4363657421,215,788
rs5590100821,200,595
rs5606138821,174,595
rs71581941021,222,355
rs72559745021,176,883
rs748911921,152,364

SLCO1B1, is a protein organic anion transporter, specific to the liver, that mediates uptake of numerous compounds and is involved in removing drugs from the blood into the liver. Variants have been connected to neonatal hyperbilirubinemia and statin response.


rs4149056, 37041T>C, the SLCO1B1*5 allele, has reduced activity, leading to higher drug concentrations and worse outcomes with statins.

Different alleles influence statin response:

  • rs72559745 (SLCO1B1*1)
  • rs56061388 (SLCO1B1*3)
  • rs4149056 (SLCO1B1*5)
  • rs55901008 (SLCO1B1*6)