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VKORC1

From SNPedia

is agene
is mentioned by
EntrezGene79001
PheGenI79001
VariationViewer79001
ClinVarVKORC1
GeneCardsVKORC1
dbSNP79001
SADR79001
HugeNav79001
wikipediaVKORC1
googleVKORC1
gopubmedVKORC1
EVSVKORC1
HEFalMpVKORC1
MyGene2VKORC1
23andMeVKORC1
# SNPs21
 Max MagnitudeChromosome positionSummary
rs104894539031,094,645
rs104894540031,094,596
rs104894541031,094,558
rs104894542031,091,243
rs17708472031,094,032
rs1787836331,096,368
rs1788062431,091,000
rs1788636931,093,188
rs2359612031,092,475
rs2884737031,094,233
rs28940303231,094,596
rs28940304231,094,558
rs28940305031,091,243
rs397509427031,096,316
rs61742245031,094,624
rs7200749031,091,268
rs72547528031,091,334
rs7294031,091,000
rs80508942.131,093,188
rs99232312.131,096,368Warfarin (Coumadin®)
rs99344382.531,093,557


The protein encoded by the VKORC1 gene is the primary target of the drug warfarin, (Coumadin), a commonly used oral anticoagulant. Several VKORC1 SNPs have been found to be predictive of warfarin dose requirement in both European and Asian-descent individuals; some are tightly linked to others and thus equivalent, at least in certain populations.

The SNPs primarily found to be associated with warfarin sensitivity include:


Polymorphisms found in another gene, cytochrome P450 2C9 (CYP2C9), also influence the metabolism of warfarin and have a smaller effect on warfarin dose. These polymorphisms are rs1799853 (CYP2C9*2) and rs1057910 (CYP2C9*3).