| Geno
|
Mag
|
Summary
|
| (C;C)
|
1.3
|
0.7x lower risk for migraines
|
| (C;T)
|
1.1
|
0.85x lower risk for migraines
|
| (T;T)
|
0
|
common in complete genomics
|
rs10166942 is a SNP on ch 2q37.1 in the TRPM8 gene.
A large GWAS study of over 5,000 patients with migraines and a meta-analysis concluded that this SNP was one of three influencing the condition, albeit with only slight risk changes on its own. The odds ratio for the less common rs10166942(C) allele was 0.85 (CI: 0.82 - 0.89, p = 5.5 x 10e-12).10.1038/ng.856
| GWAS snp
|
| PMID
|
[PMID 21666692 ]
|
| Trait
|
|
| Title
|
Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
|
| Risk Allele
|
T
|
| P-val
|
6E-12
|
| Odds Ratio
|
1.1800 [1.12-1.22]
|
[PMID 22072275] Genetics of migraine in the age of genome-wide association studies
| GWAS snp
|
| PMID
|
[PMID 22683712]
|
| Trait
|
|
| Title
|
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
|
| Risk Allele
|
|
| P-val
|
1E-12
|
| Odds Ratio
|
1.2800 None
|
[PMID 24021092] PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients
[PMID 23294458] Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine
[PMID 24674449] A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample
[PMID 30635810] rs2651899 variant is associated with risk for migraine without aura from North Indian population.
]
