rs2270954

plus

Geno	Mag	Summary
(A;A)	2	Possible increased susceptibility to schizophrenia

Make rs2270954(A;C)

Make rs2270954(C;C)

Reference

GRCh38 38.1/141

Chromosome

18

Position

53530928

Gene

DCC

is a	snp
is	mentioned by
dbSNP	rs2270954
dbSNP (classic)	rs2270954
ClinGen	rs2270954
ebi	rs2270954
HLI	rs2270954
Exac	rs2270954
Gnomad	rs2270954
Varsome	rs2270954
LitVar	rs2270954
Map	rs2270954
PheGenI	rs2270954
Biobank	rs2270954
1000 genomes	rs2270954
hgdp	rs2270954
ensembl	rs2270954
geneview	rs2270954
scholar	rs2270954
google	rs2270954
pharmgkb	rs2270954
gwascentral	rs2270954
openSNP	rs2270954
23andMe	rs2270954
SNPshot	rs2270954
SNPdbe	rs2270954
MSV3d	rs2270954
GWAS Ctlg	rs2270954

GMAF

0.1671

Max Magnitude

2

?

(A;A) (A;C) (C;C)

28

[PMID 22418395] Association between schizophrenia and genetic variation in DCC: A case-control study

The PMID above is interesting. It found an association between rs2270954 and schizophrenia. Patients were most likely to be homozygous for the minor allele. The study suggests that the DCC gene may contribute to individual genetic differences in susceptibility to schizophrenia. This SNP is located within the 3' untranslated region, an area known to contain a number of regulatory sequences that determine the stability and translation efficacy of mRNA.