rs2814707

minus

Geno	Mag	Summary
(A;A)	1.2	>1.2x increased risk for ALS
(A;G)	1.2	1.2x increased risk for ALS
(G;G)	0	normal

Reference

GRCh38 38.1/141

Chromosome

9

Position

27536399

Gene	LOC107987057

is a	snp
is	mentioned by
dbSNP	rs2814707
dbSNP (classic)	rs2814707
ClinGen	rs2814707
ebi	rs2814707
HLI	rs2814707
Exac	rs2814707
Gnomad	rs2814707
Varsome	rs2814707
LitVar	rs2814707
Map	rs2814707
PheGenI	rs2814707
Biobank	rs2814707
1000 genomes	rs2814707
hgdp	rs2814707
ensembl	rs2814707
geneview	rs2814707
scholar	rs2814707
google	rs2814707
pharmgkb	rs2814707
gwascentral	rs2814707
openSNP	rs2814707
23andMe	rs2814707
SNPshot	rs2814707
SNPdbe	rs2814707
MSV3d	rs2814707
GWAS Ctlg	rs2814707

GMAF

0.1754

Max Magnitude

1.2

?

(A;A) (A;G) (G;G)

28

rs2814707 is one of 2 SNPs from the ch 9p21.2 region associated in a large GWAS study with ALS risk, the other SNP being rs3849942. In this study, the reported odds ratio for rs2814707(A) was 1.22 (CI: 1.15 - 1.30, p = 4.72 x 10e-10).[PMID 20801717 ]

The odds ratio for the minor rs2814707(A) allele was 1.16 (p=7.45x10e-9).[PMID 19734901]

23andMe blog rs2814707(T) 1.16x odds of ALS

rs12608932(C) 1.2x odds of ALS

OMIM	105550
Desc
Variant
Related	also

[PMID 20423481 ] Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.

[PMID 20706608 ] The role of genetic variation near interferon-kappa in systemic lupus erythematosus.

[PMID 21295378] Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians.