Geno
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Mag
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Summary
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(A;A)
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normal
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(A;G)
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decreased risk of Alzheimer's disease
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(G;G)
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decreased risk of Alzheimer's disease
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A screen of SNPs in the RXRA gene in 405 Alzheimer's disease patients (mean age 74 +/- 9 years) suggests that the rs3132293(G) allele (in dbSNP orientation) is associated with lower risk for the disease.[PMID 18544046]
However, it should be noted that (1) this allele is quite common, (2) there was a significant difference in the % of females (79%) in the patient population compared to the control population (57%), and (3) the magnitude of associated changes in cerebral cholesterol is not high.
[PMID 19374686
] RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism