rs334558
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | later onset of BP |
| (A;G) | later onset of BP | |
| (G;G) | common |
| Reference | GRCh38 38.1/141 |
| Chromosome | 3 |
| Position | 120094435 |
| Gene | GSK3B, LOC107986119 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs334558 |
| dbSNP (classic) | rs334558 |
| ClinGen | rs334558 |
| ebi | rs334558 |
| HLI | rs334558 |
| Exac | rs334558 |
| Gnomad | rs334558 |
| Varsome | rs334558 |
| LitVar | rs334558 |
| Map | rs334558 |
| PheGenI | rs334558 |
| Biobank | rs334558 |
| 1000 genomes | rs334558 |
| hgdp | rs334558 |
| ensembl | rs334558 |
| geneview | rs334558 |
| scholar | rs334558 |
| rs334558 | |
| pharmgkb | rs334558 |
| gwascentral | rs334558 |
| openSNP | rs334558 |
| 23andMe | rs334558 |
| SNPshot | rs334558 |
| SNPdbe | rs334558 |
| MSV3d | rs334558 |
| GWAS Ctlg | rs334558 |
| GMAF | 0.4747 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
Although not associated with increased risk for developing bipolar disorder, amongst those with it, the (G) allele of this SNP has been reported to have a somewhat protective effect in that individuals who have a (G) allele develop bipolar disorder at a later age than those with the more common (A;A) genotypes. [PMID 15351432, PMID 14729229]
Also known as the -50T/C SNP from this GSK3-beta (GSK3B) gene.
may effect lithium treatment response - [PMID 17628506] C allele carriers showed considerably greater response with lithium treatment, with remissions of 56.25% after 4 weeks compared to 31% for T/T carriers
[PMID 19573950] GSK3beta polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort
[PMID 20055739] Role of glycogen synthase kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus
[PMID 21159074] SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study
[PMID 22119086] Gene-gene interaction of glycogen synthase kinase 3-? and serotonin transporter on human antidepressant response to sleep deprivation
[PMID 22815195] GSK3β reduces risk of sporadic Parkinson's disease in ethnic Chinese
[PMID 19154537] Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk.
[PMID 20113358] Temporal lobe grey matter volume in schizophrenia is associated with a genetic polymorphism influencing glycogen synthase kinase 3-beta activity.
[PMID 21443865] Association analysis of GSK3B and MAPT polymorphisms with Alzheimer's disease in Han Chinese.
[PMID 21527318] GSK3beta genetic variability in patients with Multiple Sclerosis.
[PMID 23021822] Glycogen synthase kinase 3β gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium
[PMID 23440732] GSK-3β Polymorphism Discriminates Bipolar Disorder and Schizophrenia: A Systematic Meta-Analysis
[PMID 21130530] Role of tau kinases (CDK5R1 and GSK3B) in Parkinson's disease: a study from India
[PMID 22990942
] Lithium and GSK3-beta promoter gene variants influence white matter microstructure in bipolar disorder.
[PMID 23030648] Possible association of the GSK3beta gene with the anxiety symptoms of major depressive disorder and P300 waveform.
[PMID 23628795] The association between glycogen synthase kinase 3 beta polymorphisms and Parkinson's disease susceptibility: a meta-analysis.
[PMID 24929537] Meta-analysis demonstrates lack of association of the GSK3B -50C/T polymorphism with risk of bipolar disorder
[PMID 24779391] MAPT rs242562 and GSK3B rs334558 are associated with Parkinson's Disease in central China
[PMID 28099358] The gender-specific association of rs334558 in GSK3β with major depressive disorder.
