rs351855
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;T) | 2 | 1.2x increased risk for prostate cancer |
| (T;T) | 2.9 | 2x increased prostate cancer risk; among breast cancer patients, herceptin is less effective |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 177093242 |
| Gene | FGFR4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs351855 |
| dbSNP (classic) | rs351855 |
| ClinGen | rs351855 |
| ebi | rs351855 |
| HLI | rs351855 |
| Exac | rs351855 |
| Gnomad | rs351855 |
| Varsome | rs351855 |
| LitVar | rs351855 |
| Map | rs351855 |
| PheGenI | rs351855 |
| Biobank | rs351855 |
| 1000 genomes | rs351855 |
| hgdp | rs351855 |
| ensembl | rs351855 |
| geneview | rs351855 |
| scholar | rs351855 |
| rs351855 | |
| pharmgkb | rs351855 |
| gwascentral | rs351855 |
| openSNP | rs351855 |
| 23andMe | rs351855 |
| SNPshot | rs351855 |
| SNPdbe | rs351855 |
| MSV3d | rs351855 |
| GWAS Ctlg | rs351855 |
| GMAF | 0.303 |
| Max Magnitude | 2.9 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs351855, a SNP in the fibroblast growth factor receptor 4 (FGFR4) gene, is also known as the Gly388Arg variant. The rs351855(T) allele encodes the risk (Arg) allele.
The Arg form of this SNP is likely to cause a harder to treat version of node-positive breast cancer, including reducing the efficacy of Herceptin, based on a study of 372 patients.[PMID 16822847]
A study of ~500 Japanese prostate cancer patients found that individuals with a rs351855(T;T) genotype had a 2.2- and 1.9-fold increased risk of prostate cancer and benign prostate hyperplasia (BPH), and a 1.8-fold increased risk of metastatic prostate cancer compared to the (C;C) genotype.[PMID 18756523]
A meta-analysis published in 2011, surveying a total of 2,618 cases of prostate cancer, concluded that the odds ratio per rs351855(T) allele was 1.17 (CI: 1.07 - 1.29), and that when stratified by race, Caucasians and Asians were at highest risk.[PMID 21349172
]
[PMID 18762813] ~1500 prostate cancer patients showed only a weak association between rs351855 and prostate-cancer specific mortality, and no evidence associating it with prostate cancer risk, disease aggressiveness, Gleason score, or stage.
[PMID 21412156] Meta and pooled analyses of FGFR4 Gly388Arg polymorphism as a cancer prognostic factor
[PMID 21656577] Association between fibroblast growth factor receptor 4 polymorphisms and risk of hepatocellular carcinoma
[PMID 22271411] Pharmacogenetics of the Effects of Colesevelam on Colonic Transit in Irritable Bowel Syndrome with Diarrhea.
[PMID 22313031] Fibroblast Growth Factor Receptor 4 Polymorphisms and Susceptibility to Coronary Artery Disease.
[PMID 22696188] Fibroblast growth factor receptor 4 polymorphisms and coronary artery disease: a case control study
| ClinVar | |
|---|---|
| Risk | Rs351855(T;T) |
| Alt | Rs351855(T;T) |
| Reference | Rs351855(C;C) |
| Significance | Pathogenic |
| Disease | Cancer progression and tumor cell motility |
| Variation | info |
| Gene | FGFR4 |
| CLNDBN | Cancer progression and tumor cell motility |
| Reversed | 1 |
| HGVS | NC_000005.9:g.176520243G>A |
| CLNSRC | OMIM Allelic Variant UniProtKB (protein) |
| CLNACC | RCV000017723.28, |
[PMID 19379518] Development of a fingerprinting panel using medically relevant polymorphisms.
[PMID 19500394] Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study.
[PMID 20565774] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
[PMID 21396369] A Klothobeta variant mediates protein stability and associates with colon transit in irritable bowel syndrome with diarrhea.
[PMID 23206452] Association between Fibroblast Growth Factor Receptor 4 Gly388Arg Polymorphism and Ischaemic Stroke
[PMID 24381107] Fibroblast growth factor receptor 4 polymorphisms and the prognosis of non-Hodgkin lymphoma
[PMID 23524567] FGFR4 genetic polymorphisms determine the chemotherapy response of Chinese patients with non-small cell lung cancer
[PMID 26431494] Association of FGFR3 and FGFR4 gene polymorphisms with breast cancer in Chinese women of Heilongjiang province
[PMID 31878098] Involvement of FGFR4 Gene Variants on the Clinicopathological Severity in Urothelial Cell Carcinoma.
