rs402710
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 1.9 | Common, but higher lung cancer risk ? |
| Make rs402710(C;T) |
| Make rs402710(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 1320607 |
| Gene | CLPTM1L |
| is a | snp |
| is | mentioned by |
| dbSNP | rs402710 |
| dbSNP (classic) | rs402710 |
| ClinGen | rs402710 |
| ebi | rs402710 |
| HLI | rs402710 |
| Exac | rs402710 |
| Gnomad | rs402710 |
| Varsome | rs402710 |
| LitVar | rs402710 |
| Map | rs402710 |
| PheGenI | rs402710 |
| Biobank | rs402710 |
| 1000 genomes | rs402710 |
| hgdp | rs402710 |
| ensembl | rs402710 |
| geneview | rs402710 |
| scholar | rs402710 |
| rs402710 | |
| pharmgkb | rs402710 |
| gwascentral | rs402710 |
| openSNP | rs402710 |
| 23andMe | rs402710 |
| SNPshot | rs402710 |
| SNPdbe | rs402710 |
| MSV3d | rs402710 |
| GWAS Ctlg | rs402710 |
| GMAF | 0.3618 |
| Max Magnitude | 1.9 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 18978790 ]
|
| Trait | Lung cancer |
| Title | Lung cancer susceptibility locus at 5p15.33 |
| Risk Allele | C |
| P-val | 0.000004 |
| Odds Ratio | 1.18 [1.12-1.24] |
[PMID 19465454] The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung
[PMID 20056643] A rigorous and comprehensive validation: common genetic variations and lung cancer
[PMID 21750227] Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC)
[PMID 22404340] Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population
[PMID 22653581] A common genetic variant of 5p15.33 is associated with risk for prostate cancer in the Chinese population
[PMID 21966413] Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population
[PMID 19369581] Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population.
[PMID 19654303] Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
[PMID 19836008] A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
[PMID 20101243] A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
[PMID 20548021] Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.
[PMID 20628624] Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
[PMID 20700438] The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia.
[PMID 21081471] Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study.
[PMID 21304900] Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD.
[PMID 22228261] Common genetic variants in TERT contribute to risk of cervical cancer in a Chinese population.
[PMID 22370939] Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma.
[PMID 22523397] Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis.
[PMID 24194831] The SNP rs402710 in 5p15.33 Is Associated with Lung Cancer Risk: A Replication Study in Chinese Population and a Meta-Analysis
[PMID 23085811] Tobacco consumption and genetic susceptibility to nasopharyngeal carcinoma (NPC) in Thailand.
[PMID 24907075] Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies
[PMID 24615522] Quantitative assessment of common genetic variants on chromosome 5p15 and lung cancer risk
[PMID 25155038] Correlation of CLPTM1L polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population
[PMID 29939218] rs401681 and rs402710 confer lung cancer susceptibility by regulating TERT expression instead of CLPTM1L in East Asian.
