rs6505162

plus

Geno	Mag	Summary
(A;A)	2.1	0.43x decreased risk for esophageal cancer
(A;C)	2	0.58x decreased risk for esophageal cancer
(C;C)	1.5	normal

Reference

GRCh38 38.1/141

Chromosome

17

Position

30117165

Gene	MIR3184, MIR423, NSRP1

is a	snp
is	mentioned by
dbSNP	rs6505162
dbSNP (classic)	rs6505162
ClinGen	rs6505162
ebi	rs6505162
HLI	rs6505162
Exac	rs6505162
Gnomad	rs6505162
Varsome	rs6505162
LitVar	rs6505162
Map	rs6505162
PheGenI	rs6505162
Biobank	rs6505162
1000 genomes	rs6505162
hgdp	rs6505162
ensembl	rs6505162
geneview	rs6505162
scholar	rs6505162
google	rs6505162
pharmgkb	rs6505162
gwascentral	rs6505162
openSNP	rs6505162
23andMe	rs6505162
SNPshot	rs6505162
SNPdbe	rs6505162
MSV3d	rs6505162
GWAS Ctlg	rs6505162

GMAF

0.4885

Max Magnitude

2.1

?

(A;A) (A;C) (C;C)

28

rs6505162 is a SNP located in the pre-miRNA region of mir423. The major allele is rs6505162(C).

A study of 346 Caucasians with esophageal cancer found that compared with the homozygous wild-type genotype of rs6505162, individuals with the heterozygous and homozygous variant genotype had a significantly reduced esophageal cancer risk with odds ratios of 0.58 (CI: 0.41-0.82) and 0.43 (CI: 0.27-0.68), respectively. After stratifying by gender, smoking, and age, the authors discovered that the protective effect was significant only for individuals under 64 years of age, regardless of sex or whether they smoked. Other unfavorable genotypes (ie SNPs) were also identified that were not as significant as rs6505162, and the overall risk of esophageal cancer increased with increasing numbers of unfavorable SNPs.10.1158/1940-6207.CAPR-08-0135 [PMID 19138993 ]

snp near microRNA
ACC	MI0001445
ID	hsa-mir-423
offset	-39

discussed in nature

[PMID 19950226] SNPs in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high risk women

[PMID 22028396 ] Genetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer

[PMID 22593246] A Genetic Variant Located in miR-423 is Associated with Reduced Breast Cancer Risk

[PMID 18521189 ] Genetic variants of miRNA sequences and non-small cell lung cancer survival.

[PMID 19047128 ] Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

[PMID 19458495 ] Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.

[PMID 22818121] The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer

[PMID 24205249 ] MicroRNA Polymorphisms and Environmental Smoke Exposure as Risk Factors for Oesophageal Squamous Cell Carcinoma

[PMID 24413317 ] MicroRNA sequence polymorphisms and the risk of different types of cancer

[PMID 24854593 ] Identification of miR-423 and miR-499 Polymorphisms on Affecting the Risk of Hepatocellular Carcinoma in a Large-Scale Population

[PMID 25663458] Genetic analysis and preliminary function study of miR-423 in breast cancer

[PMID 25901206 ] Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease

[PMID 25926693] The polymorphism of rs6505162 in miR-423 coding region and recurrent pregnancy loss

[PMID 26518769] Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population

[PMID 27421647 ] Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population.

[PMID 29419695 ] Association of microRNA-423 rs6505162 C>A polymorphism with susceptibility and metastasis of colorectal carcinoma.

[PMID 30256064 ] Involvement of microRNA-423 Gene Variability in Breast Cancer Progression in Saudi Arabia

[PMID 30503865] Haplotype-based association of two SNPs in miR-423 with unexplained recurrent pregnancy loss in a Chinese Han population.