| Geno
|
Mag
|
Summary
|
| (G;G)
|
0
|
common/normal
|
| (G;T)
|
2
|
1.5x increased risk for epithelial ovarian cancer
|
| (T;T)
|
2.2
|
2.25x increased risk for epithelial ovarian cancer
|
rs7651446 is a SNP within the TCDD-inducible poly(ADP-ribose) polymerase TIPARP gene on chromosome 3.
Although not the first report, the first large validation associating the rs7651446(T) allele with increased risk for epithelial ovarian cancer came from a study of 18,174 individuals from 43 studies from the Ovarian Cancer Association Consortium.[PMID 23535730
] Subsequently, another study of over 18,000 patients, including BRCA1 and BRCA2 carriers as well as a meta-analysis, validated this association as the strongest (in terms of increasing risk) of a total of 18 known risk loci. The rs7651466(T) allele was reported as having a hazard ratio of between 1.50 - 1.94, depending on genetic background, with p values 10e-8 or lower.[PMID 25581431]
| GWAS snp
|
| PMID
|
[PMID 23535730]
|
| Trait
|
Ovarian cancer
|
| Title
|
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
| Risk Allele
|
|
| P-val
|
2E-29
|
| Odds Ratio
|
1.44 [1.35-1.54]
|
] Subsequently, another study of over 18,000 patients, including BRCA1 and BRCA2 carriers as well as a meta-analysis, validated this association as the strongest (in terms of increasing risk) of a total of 18 known risk loci. The rs7651466(T) allele was reported as having a hazard ratio of between 1.50 - 1.94, depending on genetic background, with p values 10e-8 or lower.[PMID 25581431
