rs7657958
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs7657958(A;A) |
| Make rs7657958(A;G) |
| Make rs7657958(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 68817077 |
| Gene | UGT2B10 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7657958 |
| dbSNP (classic) | rs7657958 |
| ClinGen | rs7657958 |
| ebi | rs7657958 |
| HLI | rs7657958 |
| Exac | rs7657958 |
| Gnomad | rs7657958 |
| Varsome | rs7657958 |
| LitVar | rs7657958 |
| Map | rs7657958 |
| PheGenI | rs7657958 |
| Biobank | rs7657958 |
| 1000 genomes | rs7657958 |
| hgdp | rs7657958 |
| ensembl | rs7657958 |
| geneview | rs7657958 |
| scholar | rs7657958 |
| rs7657958 | |
| pharmgkb | rs7657958 |
| gwascentral | rs7657958 |
| openSNP | rs7657958 |
| 23andMe | rs7657958 |
| SNPshot | rs7657958 |
| SNPdbe | rs7657958 |
| MSV3d | rs7657958 |
| GWAS Ctlg | rs7657958 |
| GMAF | 0.05556 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs7657958 (Asp67Tyr, 199G>T) is a SNP within the UGT2B10 (UDP-glucuronosyltransferase 2B10) gene.
[PMID 18300939] Tyr allele defines haplotype C, significantly associated with lower 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, a nitrosamine found in tobacco) N-glucuronidation, an 1.8-fold and 12-fold reduction in NNAL-N-glucuronidation was found for one and two haplotype C alleles, respectively
[PMID 19786624
] may effect nicotine metabolism
