Geno
|
Mag
|
Summary
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(C;C)
|
1
|
lower bone mineral density in postmenopausal Korean women
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(C;T)
|
1
|
higher bone mineral density in postmenopausal Spanish women
|
(T;T)
|
0
|
normal
|
rs7771980, also known as -1025T>C, is a SNP in the RUNX2 gene, which encodes an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification.
This SNP has been reported to be significantly associated with bone mineral density (BMD; and thus osteoporosis in several studies, but with different correlations.
In a study of 821 Spanish postmenopausal women, rs7771980(C;T) women had higher mean adjusted femoral neck bone BMD values than those bearing the (T;T) genotype.[PMID 17878995]
In a study of 729 postmenopausal Korean women, the significant association found was that (C;C) women showed a significant association with reduced lumbar spine BMD and proximal femur sites compared with (C;T) or (T;T) subjects.[PMID 19424741]
[PMID 18357615] Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations.