| Geno
|
Mag
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Summary
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| (C;C)
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0
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common in complete genomics
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| (C;T)
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1
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~0.80x (lower) risk for late onset Alzheimer's disease
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| (T;T)
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1
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~0.80x (lower) risk for late onset Alzheimer's disease
|
rs7910977 is a SNP of the IDE gene, which encodes the insulin-degrading enzyme.
Late onset Alzheimer's disease is a neurodegenerative condition in which the brain develops large numbers of extracellular senile plaques composed primarily of aggregated amyloid-B proteins as well as intraneuronal neurofibrillary tangles composed mainly of aggregated tau protein.[PMID 15450169] One notable function of insulin-degrading enzyme is its ability to degrade amyloid-B and therefore to influence the amount of amyloid-B found in the brain.[PMID 12634421
]
The rs7910977(T) allele is associated with reduced risk of Alzheimer's disease in one study of ~3,000 patients, and in this study, the conclusion was that it was most likely due to near perfect linkage with rs6583817, a nearby functional variant. rs6583817(T) allele carriers had an odds ratio for late onset Alzheimer's disease of around 0.80 (p<0.03).[PMID 20098734]
[PMID 20142614] Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease
[PMID 24477584] Genetic association of IDE, POU2F1, PON1, IL1α and IL1β with type 2 diabetes in Pakistani population
]
