rs9296249

plus

Geno	Mag	Summary
(C;C)		<0.62x risk for restless legs
(C;T)		0.62x risk for restless legs
(T;T)	0	common

Reference

GRCh38 38.1/141

Chromosome

6

Position

38398065

Gene

BTBD9

is a	snp
is	mentioned by
dbSNP	rs9296249
dbSNP (classic)	rs9296249
ClinGen	rs9296249
ebi	rs9296249
HLI	rs9296249
Exac	rs9296249
Gnomad	rs9296249
Varsome	rs9296249
LitVar	rs9296249
Map	rs9296249
PheGenI	rs9296249
Biobank	rs9296249
1000 genomes	rs9296249
hgdp	rs9296249
ensembl	rs9296249
geneview	rs9296249
scholar	rs9296249
google	rs9296249
pharmgkb	rs9296249
gwascentral	rs9296249
openSNP	rs9296249
23andMe	rs9296249
SNPshot	rs9296249
SNPdbe	rs9296249
MSV3d	rs9296249
GWAS Ctlg	rs9296249

GMAF

0.3815

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

rs9296249, a SNP located in the BTBD9 gene region, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.62 (CI: 0.52-0.75) for the (C) minor allele. [PMID 17637780]

GWAS
SNP	rs9296249
PubMedID	[PMID 17637780]
Condition	Restless legs syndrome
Gene	BTBD9
Risk Allele	T
pValue	4.00E-018
OR	1.67
95% CI	1.49-1.89

OMIM	611185
Desc	RESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 6
Variant
Related	also

[PMID 19223043] Exploring the genetic link between RLS and ADHD

[PMID 19279021 ] Replication of restless legs syndrome loci in three European populations.

[PMID 22914617] Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.

[PMID 22486183] A genetic risk factor for low serum ferritin levels in Danish blood donors. Homozygosity for the T-allele of BTBD9 rs9296249 was associated with lower serum ferritin. The odds ratio for low serum ferritin was 1.35 (95% confidence interval, 1.02-1.77; p=0.03) when comparing donors with the TT genotype with donors with the CT genotype.

[PMID 28329290] Association of BTBD9 and MAP2K5/SKOR1 With Restless Legs Syndrome in Chinese Population.