Eczema

Eczema is a general term referring to a group of problematic skin conditions, most often including symptoms such as itching, dryness, redness, and blistering. Wikipedia

One distinction often made is between atopic eczema and nonatopic eczema forms, which are characterized by the presence or absence, respectively, of allergen-specific IgE.

Atopic eczema (an allergic disease) has been reported to be associated with many SNPs, including some in the CARD11 gene as well as the following (primarily from [PMID 26482879]):

SNP	Alleles (effect/other)	Freq. (effect allele)	OR (CI)	p
rs10199605	A/G	0.3	0.93 (0.90–0.95)	3.4 × 10−8
rs10214237	C/T	0.27	0.93 (0.90–0.95)	2.9 × 10−8
rs10791824	G/A	0.57	1.12 (1.09–1.15)	2.1 × 10−19
rs112111458	G/A	0.13	0.91 (0.87–0.94)	1.4 × 10−7
rs12188917	C/T	0.21	1.14 (1.10–1.17)	4.0 × 10−17
rs12730935	A/G	0.39	1.08 (1.05–1.11)	6.1 × 10−11
rs12951971	G/T	0.09	1.13 (1.08–1.17)	4.1 × 10−8
rs145809981	T/C	0.14	0.91 (0.88–0.95)	1.5 × 10−6
rs2038255	T/C	0.18	1.11 (1.07–1.14)	1.8 × 10−10
rs2041733	C/T	0.55	0.92 (0.90–0.94)	2.5 × 10−11
rs2212434	T/C	0.45	1.09 (1.07–1.12)	4.6 × 10−13
rs2592555	C/T	0.27	0.93 (0.90–0.96)	8.7 × 10−7
rs2918307	G/A	0.16	1.12 (1.08–1.16)	4.6 × 10−12
rs2944542	C/G	0.41	0.94 (0.92–0.96)	1.2 × 10−6
rs4643526	A/G	0.19	1.09 (1.06–1.12)	3.5 × 10−8
rs4713555	T/G	0.27	0.91 (0.89–0.94)	5.4 × 10−9
rs4809219	C/A	0.27	0.90 (0.87–0.93)	7.0 × 10−13
rs61813875	G/C	0.02	1.61 (1.48–1.75)	5.6 × 10−29
rs6419573	T/C	0.26	1.11 (1.08–1.14)	1.5 × 10−13
rs6473227	A/C	0.61	0.93 (0.91–0.95)	1.4 × 10−9
rs6602364	G/C	0.45	1.08 (1.05–1.10)	1.5 × 10−9
rs7127307	C/T	0.47	0.93 (0.90–0.95)	3.9 × 10−10
rs7512552	T/C	0.49	0.93 (0.91–0.95)	9.1 × 10−10
rs7625909	T/C	0.32	1.07 (1.05–1.10)	4.9 × 10−8
rs1800875

Nonatopic eczema is reported to be associated with SNPs in the IL31 gene, including:

• rs6489188
• rs11608363

[PMID 25009230] Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema, based on expression of CCL27 and NOS2