Glyburide
From SNPedia
Glibenclamide, also known as glyburide, is an antidiabetic drug in a class of medications known as sulfonylureas, closely related to sulfonamide antibiotics. It is used in the treatment of type-2 diabetes. As of 2003, in the United States, it was the most popular sulfonylurea.Wikipedia
| Genotype/Genoset | Diplotype | Gene | Drug Use/Category/Class | Medical Field | Summary | Descriptive Sentence |
|---|---|---|---|---|---|---|
| gs309 | WT/WT | G6PD | Diabetes | Endocrinology | Normal Response Expected | You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia). |
| gs307 | Carrier | G6PD | Diabetes | Endocrinology | Consider Alternatives | You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking glyburide; due to variable expression (i.e. in females), enzymatic testing for G6PD activity is advisable. |
| gs308 | G6PD-deficient | G6PD | Diabetes | Endocrinology | Consider Alternatives | You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia) when taking glyburide; use caution and consider non-sulfonylurea alternatives. |
