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From SNPedia

Metoprolol is the generic name of a drug in the beta blocker class, typically used in the treatment of high blood pressure. Trade names for metoprolol include Lopressor, Toprol-XL, Seleken, Minax, Metrol, Betaloc, Neobloc, Corvitol.

SNPs in the ADRB1 gene may influence how well metoprolol will help lower a patient's high blood pressure; for examples, see rs1801252 and rs1801253.

[PMID 18784654] CYP2D6*4 homozygotes taking a beta blocker like metoprolol are at 4x increased risk for bradycardia; see rs3892097 for more details

See also: genoset gs185 for a related blood pressure effect connected to this drug.