NLRP1
From SNPedia
| is a | gene |
| is | mentioned by |
| ClinVar | NLRP1 |
| GeneCards | NLRP1 |
| Diseases | NLRP1 |
| wikipedia | NLRP1 |
| NLRP1 | |
| gopubmed | NLRP1 |
| EVS | NLRP1 |
| HEFalMp | NLRP1 |
| MyGene2 | NLRP1 |
| 23andMe | NLRP1 |
| # SNPs | 11 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1057519492 | 0 | 5,583,798 | |
| rs1057519493 | 0 | 5,583,761 | |
| rs1057524876 | 0 | 5,521,666 | |
| rs115799546 | 7 | 5,558,964 | |
| rs11651270 | 0 | 5,521,757 | |
| rs11657747 | 0 | 5,541,923 | |
| rs12150220 | 0 | 5,582,047 | |
| rs397514692 | 0 | 5,583,728 | |
| rs6502867 | 0 | 5,517,008 | |
| rs776245016 | 0 | 5,558,520 | |
| rs8079034 | 0 | 5,509,041 |
The NLRP1 gene provides instructions for making a member of a family of proteins called nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins. These proteins are involved in the immune system, helping to regulate the process of inflammation. Inflammation occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight microbial invaders and facilitate tissue repair. The body then stops (inhibits) the inflammatory response to prevent damage to its own cells and tissues.GHR
Mutations in the NLRP1 gene have been associated with several autoimmune diseases (including Addison's disease and multiple sclerosis) as well with malignant melanoma.
