Non-Hodgkin Lymphoma

As the WikiPedia page on Lymphomas details, Non-Hodgkin Lymphoma (NHL) refers to all lymphoma types other than Hodgkin lymphoma.

A study of 458 Caucasian non-Hodgkin lymphoma patients found SNP associations both at the level of certain genes and at individual SNPs. [PMID 17827388]

Variations of the following genes were implicated in risk for one or more types of NHL:

• Genes associated with immune response:
  • TRAF1
  • RIPK3
  • BAT2
  • TLR6
• Genes involved in mitogen signalling:
  • MAP3K
  • DUSP2
  • CREB1
• Genes involved in lymphocyte trafficking or migration:
  • B3GNT3
  • SELPLG
  • LSP1
• Genes in coagulation pathways:
  • FGG
  • ITGB3

For individual SNPs, the most significant (p<0.01) findings were for:

• rs5918, ITGB3 L59P (OR = 0.66, CI: 0.52-0.85)
• rs5743815, TLR6 V427A (OR = 5.20, CI: 1.77-15.3)
• rs7300972, SELPLG M264V (OR = 3.20, CI: 1.48-6.91)
• rs2072797, UNC84B G671S (OR = 1.50, CI: 1.12-2.00)
• rs36686, B3GNT3 H328R (OR = 0.74, CI: 0.59-0.93)
• rs3132453, BAT2 V1883L (OR = 0.64, CI: 0.45-0.90)
• rs10008492, in a toll-like receptor gene cluster
• rs4833103, in the same toll-like receptor gene cluster