ORMDL3
| is a | gene |
| is | mentioned by |
| Full name | ORM1-like 3 (S. cerevisiae) |
| EntrezGene | 94103 |
| PheGenI | 94103 |
| VariationViewer | 94103 |
| ClinVar | ORMDL3 |
| GeneCards | ORMDL3 |
| dbSNP | 94103 |
| Diseases | ORMDL3 |
| SADR | 94103 |
| HugeNav | 94103 |
| wikipedia | ORMDL3 |
| ORMDL3 | |
| gopubmed | ORMDL3 |
| EVS | ORMDL3 |
| HEFalMp | ORMDL3 |
| MyGene2 | ORMDL3 |
| 23andMe | ORMDL3 |
| UniProt | Q8N138 |
| Ensembl | ENSG00000172057 |
| OMIM | 610075 |
| # SNPs | 7 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs12603332 | 0 | 39,926,554 | |
| rs17608925 | 0 | 39,926,578 | |
| rs3169572 | 0 | 39,921,159 | |
| rs3744246 | 0 | 39,928,097 | |
| rs4065275 | 0 | 39,924,612 | |
| rs4378650 | 0 | 39,924,612 | |
| rs8076131 | 0 | 39,924,659 |
The ORMDL3 gene on chromosome 17q21 has been associated with asthma in several studies. SNPs either in or near enough to influence ORMDL3 include:
[PMID 18923164] and NEJM conclude the following: "This study shows that the increased risk of asthma conferred by 17q21 genetic variants is restricted to early-onset asthma and that the risk is further increased by early-life exposure to environmental tobacco smoke." {Note: early-onset refers to the onset of asthma at the age of 4 years or younger.} The ch 17q21 SNPs mentioned in this article are:
These authors are uncertain of the role played by the ORMDL3 gene, and mention 3 other genes also in the 17q21 region which might be involved instead of (or in addition to) ORMDL2: ZPBP2, IKZF3, and GSDML.
