[PMID 29357674] Associating Symptom Phenotype and Genotype in Preeclampsia.
[PMID 29196994] Genetic Approaches in Preeclampsia.
[PMID 28611769] Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia.
[PMID 27755385] The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia..
[PMID 23551011] Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
[PMID 22432041] Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene.
[PMID 15806103] Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family.
Reported genes and SNPs
- Reported genes: FGF14, MYCBP2, ZNF295-AS1, MCM8, MGC45800, LZTS1, INVS, ERP44, WWTR1, SFR1, MUC21, TGFBRAP1, LHFP, RUNX1, BAMBI, NPVF, SCN2B, ADRA1D
- Reported SNPs:
Several other SNPs have been described as increasing the risk of developing pre-eclampsia, including:
- rs5186, in the AGTR1 gene
- rs4762, in the AGT gene, plus others in AGT
- rs1799983, in the NOS3 gene
- rs1982073, in the TGFB1 gene. The rs1982073(T) allele is more common in women who develop pre-eclampsia with severe renal complications. However, it is not associated with overall risk of pre-eclampsia.
|Title||Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.|