Pre-eclampsia
Pre-eclampsia is caused by pregnancy-induced hypertension. It is also known as gestational hypertension.
Publications[edit]
[PMID 29967039
] Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1.
[PMID 29357674] Associating Symptom Phenotype and Genotype in Preeclampsia.
[PMID 29196994] Genetic Approaches in Preeclampsia.
[PMID 28611769] Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia.
[PMID 27755385] The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia..
[PMID 23976997] The common variant rs11646213 is associated with preeclampsia in Han Chinese women.
[PMID 23551011] Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
[PMID 22432041] Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene.
[PMID 15806103] Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family.
Reported genes and SNPs[edit]
- Reported genes: FGF14, MYCBP2, ZNF295-AS1, MCM8, MGC45800, LZTS1, INVS, ERP44, WWTR1, SFR1, MUC21, TGFBRAP1, LHFP, RUNX1, BAMBI, NPVF, SCN2B, ADRA1D
- Reported SNPs:
- rs366510
- rs975369
- rs1248993
- rs1556832
- rs2241391
- rs2287845
- rs2287848
- rs2839440
- rs4815879
- rs6563695
- rs7028939
- rs7322722
- rs9976946
- rs10883969
- rs10989019
- rs11600901
- rs12641856
- rs17412740
- rs17636747
- rs17787940
- rs11617740
- rs28360974
- rs183805948
- rs190390034
Several other SNPs have been described as increasing the risk of developing pre-eclampsia, including:
- rs5186, in the AGTR1 gene
- rs4762, in the AGT gene, plus others in AGT
- rs1799983, in the NOS3 gene
- rs1982073, in the TGFB1 gene. The rs1982073(T) allele is more common in women who develop pre-eclampsia with severe renal complications. However, it is not associated with overall risk of pre-eclampsia.
| GWAS snp | |
|---|---|
| PMID | [PMID 23551011]
|
| Trait | |
| Title | Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort. |
| Risk Allele | |
| P-val | |
| Odds Ratio | |
