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Pre-eclampsia

From SNPedia


Pre-eclampsia is caused by pregnancy-induced hypertension. It is also known as gestational hypertension.

Publications[edit]

[PMID 29967039OA-icon.png] Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1.

[PMID 29357674] Associating Symptom Phenotype and Genotype in Preeclampsia.

[PMID 29196994] Genetic Approaches in Preeclampsia.

[PMID 28611769OA-icon.png] Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia.

[PMID 27755385OA-icon.png] The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia..

[PMID 23976997OA-icon.png] The common variant rs11646213 is associated with preeclampsia in Han Chinese women.

[PMID 23551011OA-icon.png] Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.

[PMID 22432041] Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene.

[PMID 15806103] Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family.

Reported genes and SNPs[edit]

Several other SNPs have been described as increasing the risk of developing pre-eclampsia, including:

  • rs5186, in the AGTR1 gene
  • rs4762, in the AGT gene, plus others in AGT
  • rs1799983, in the NOS3 gene
  • rs1982073, in the TGFB1 gene. The rs1982073(T) allele is more common in women who develop pre-eclampsia with severe renal complications. However, it is not associated with overall risk of pre-eclampsia.
GWAS snp
PMID [PMID 23551011OA-icon.png]
Trait
Title Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
Risk Allele
P-val
Odds Ratio