Spontaneous premature birth (<37 weeks gestation; also known as preterm birth or PTB) occurs in approximately 12% of pregnancies in the United States, and is the largest contributor to neonatal morbidity and mortality. Wikipedia
Evidence is increasing for a role of SNPs in either maternal or fetal DNA in increasing risk for preterm birth. SNPs potentially involved include:
- In maternal DNA:
- In fetal DNA:
- rs17121510, in the interleukin-10 receptor antagonist (IL-10RA) gene
- rs4696480 (T-16934A and Arg753Gln) and rs5743708) (Thr399Ile) earlier birth for infants carrying two (-16934TA/AA and 753ArgGln/GlnGln) [PMID 17667860]
- [PMID 16938879] A snp in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans.