rs10505477
| Orientation | minus |
| Stabilized | minus |
| Make rs10505477(C;C) |
| Make rs10505477(C;T) |
| Make rs10505477(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 8 |
| Position | 127395198 |
| Gene | CASC8 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10505477 |
| dbSNP (classic) | rs10505477 |
| ClinGen | rs10505477 |
| ebi | rs10505477 |
| HLI | rs10505477 |
| Exac | rs10505477 |
| Gnomad | rs10505477 |
| Varsome | rs10505477 |
| LitVar | rs10505477 |
| Map | rs10505477 |
| PheGenI | rs10505477 |
| Biobank | rs10505477 |
| 1000 genomes | rs10505477 |
| hgdp | rs10505477 |
| ensembl | rs10505477 |
| geneview | rs10505477 |
| scholar | rs10505477 |
| rs10505477 | |
| pharmgkb | rs10505477 |
| gwascentral | rs10505477 |
| openSNP | rs10505477 |
| 23andMe | rs10505477 |
| SNPshot | rs10505477 |
| SNPdbe | rs10505477 |
| MSV3d | rs10505477 |
| GWAS Ctlg | rs10505477 |
| GMAF | 0.461 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 18056436] Associated with risk of colorectal cancer; (P = 0.005)
[PMID 18839428] colorectal cancer rs10505477 and rs6983267 yielded allelic p-values of 1.42 x 10(-7) and 2.57 x 10(-7), respectively with OR=1.50 (95% CI: 1.29-1.75). Risk region was delineated by SNPs rs10505477 and rs7014346 and comprised 17 kb
| GWAS | |
|---|---|
| SNP | rs10505477 |
| PubMedID | [PMID 17618283] |
| Condition | Colorectal cancer |
| Gene | ORF DQ515897 |
| Risk Allele | A |
| pValue | 3.00E-011 |
| OR | 1.17 |
| 95% CI | 1.12-1.23 |
[PMID 21102338
] Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer
[PMID 21129217] Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
[PMID 21722176] Association of 8q24.21 locus with the risk of colorectal cancer: A systematic review and meta-analysis
[PMID 22505654] GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes
[PMID 17630503] Genetic variation in 8q24 associated with risk of colorectal cancer.
[PMID 18372901] Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
[PMID 18535017] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.
[PMID 18577746] Multiple loci with different cancer specificities within the 8q24 gene desert.
[PMID 18670647] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
[PMID 18973230] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
[PMID 19155440] Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.
[PMID 19520795] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.
[PMID 20158306] Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.
[PMID 20437058] The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.
[PMID 21455501] Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.
[PMID 23677573] Genome-wide association study identifies possible genetic risk factors for colorectal adenomas
[PMID 22848671] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
[PMID 24854447] Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population
[PMID 24978480] A Colorectal Cancer Susceptibility New Variant at 4q26 in the Spanish Population Identified by Genome-Wide Association Analysis
| GWAS snp | |
|---|---|
| PMID | [PMID 24740154]
|
| Trait | Prostate cancer (early onset) |
| Title | Genome-wide association scan for variants associated with early-onset prostate cancer. |
| Risk Allele | A |
| P-val | 9E-9 |
| Odds Ratio | 1.39 [1.28-1.50] |
| GWAS snp | |
|---|---|
| PMID | [PMID 24737748]
|
| Trait | Colorectal cancer |
| Title | Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. |
| Risk Allele | T |
| P-val | 8E-13 |
| Odds Ratio | 1.20 [NR] |
[PMID 26579801] Correlation Between CASC8, SMAD7 Polymorphisms and the Susceptibility to Colorectal Cancer: An Updated Meta-Analysis Based on GWAS Results
[PMID 26885031] Association of 8q23-24 region (8q23.3 loci and 8q24.21 loci) with susceptibility to colorectal cancer: a systematic and updated meta-analysis.
[PMID 27249003] Clinical Significance of Long Non-Coding RNA CASC8 rs10505477 Polymorphism in Lung Cancer Susceptibility, Platinum-Based Chemotherapy Response, and Toxicity.
[PMID 27689194] Single Nucleotide Polymorphisms within the 8Q24 Region are Not Associated with the Risk of Intraductal Papillary Mucinous Neoplasms of the Pancreas.
[PMID 27769063] Risk of eighteen genome-wide association study-identified genetic variants for colorectal cancer and colorectal adenoma in Han Chinese.
