|?|| (C;C) (C;T) (T;T) ||28|
In a survey that scanned 80 genes, no SNPs with a large effect were found to be associated with bipolar disorder
. However, the SNP with the largest association was rs1170191
, in first intron of the diacylglycerol kinase eta DGKH
gene. The odds ratio for the risk allele of this SNP is 1.59 (p = 1.5x10e-8, experiment-wide p<0.01).[PMID 17486107
[PMID 18421293] Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement.
[PMID 19308021] Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.
[PMID 19818381] Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients.
[PMID 22048461] Effect of variation in diacylglycerol kinase eta (DGKH) gene on brain function in a cohort at familial risk of bipolar disorder.