rs174546
| Orientation | plus |
| Stabilized | plus |
| Make rs174546(C;C) |
| Make rs174546(C;T) |
| Make rs174546(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 61802358 |
| Gene | FADS1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs174546 |
| dbSNP (classic) | rs174546 |
| ClinGen | rs174546 |
| ebi | rs174546 |
| HLI | rs174546 |
| Exac | rs174546 |
| Gnomad | rs174546 |
| Varsome | rs174546 |
| LitVar | rs174546 |
| Map | rs174546 |
| PheGenI | rs174546 |
| Biobank | rs174546 |
| 1000 genomes | rs174546 |
| hgdp | rs174546 |
| ensembl | rs174546 |
| geneview | rs174546 |
| scholar | rs174546 |
| rs174546 | |
| pharmgkb | rs174546 |
| gwascentral | rs174546 |
| openSNP | rs174546 |
| 23andMe | rs174546 |
| SNPshot | rs174546 |
| SNPdbe | rs174546 |
| MSV3d | rs174546 |
| GWAS Ctlg | rs174546 |
| GMAF | 0.3297 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 19060910 ]
|
| Trait | LDL cholesterol |
| Title | Genome-wide association analysis of metabolic traits in a birth cohort from a founder population |
| Risk Allele | G |
| P-val | 1E-7 |
| Odds Ratio | 0.96 [0.06-0.13] mmol/l decrease |
[PMID 20484448] Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study
| GWAS snp | |
|---|---|
| PMID | [PMID 20694148]
|
| Trait | |
| Title | A genome-wide association study of the metabolic syndrome in Indian Asian men |
| Risk Allele | A |
| P-val | 6E-7 |
| Odds Ratio | 0.03 [0.02-0.04] mmol/l decrease |
| GWAS snp | |
|---|---|
| PMID | [PMID 20686565]
|
| Trait | |
| Title | Biological, clinical and population relevance of 95 loci for blood lipids. |
| Risk Allele | T |
| P-val | 5E-24 |
| Odds Ratio | 3.8200 None |
[PMID 19148276] Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study.
[PMID 19798445] Genetic determinants of circulating sphingolipid concentrations in European populations.
[PMID 20427696] Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.
[PMID 20562440] FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.
[PMID 20565855] Genetic variation in lipid desaturases and its impact on the development of human disease.
[PMID 20691134] Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.
[PMID 21593353] FADS1 genetic variability interacts with dietary alpha-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents.
[PMID 21793953] FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children.
[PMID 23016130] Association between Polymorphisms in the Fatty Acid Desaturase Gene Cluster and the Plasma Triacylglycerol Response to an n-3 PUFA Supplementation
[PMID 24890013] Genetic predisposition scores for dyslipidaemia influence plasma lipid concentrations at baseline, but not the changes after controlled intake of n-3 polyunsaturated fatty acids
[PMID 25008580] Genetic Variation in FADS Has Little Effect on the Association between Dietary PUFA Intake and Cardiovascular Disease
| GWAS snp | |
|---|---|
| PMID | [PMID 24097068]
|
| Trait | Cholesterol, total |
| Title | Discovery and refinement of loci associated with lipid levels. |
| Risk Allele | T |
| P-val | 3E-37 |
| Odds Ratio | .05 [NR] unit decrease |
[PMID 26261632] Association of two polymorphisms in the FADS1/FADS2 gene cluster and the risk of coronary artery disease and ischemic stroke
[PMID 31991592] Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome.
[PMID 32502762] FADS1 and ELOVL2 polymorphisms reveal associations for differences in lipid metabolism in a cross-sectional population-based survey of Brazilian men and women.
