| GWAS snp
|
| PMID
|
[PMID 19060906 ]
|
| Trait
|
HDL cholesterol
|
| Title
|
Common variants at 30 loci contribute to polygenic dyslipidemia
|
| Risk Allele
|
C
|
| P-val
|
2E-12
|
| Odds Ratio
|
0.09 [0.05-0.13] SD decrease
|
| GWAS snp
|
| PMID
|
[PMID 20037589]
|
| Trait
|
Serum metabolites
|
| Title
|
A genome-wide perspective of genetic variation in human metabolism
|
| Risk Allele
|
T
|
| P-val
|
0
|
| Odds Ratio
|
36.30 [NR] % variance explained
|
| GWAS snp
|
| PMID
|
[PMID 20639392]
|
| Trait
|
Resting heart rate
|
| Title
|
Genome-wide association analysis identifies multiple loci related with resting heart rate
|
| Risk Allele
|
C
|
| P-val
|
2E-9
|
| Odds Ratio
|
6.20 [4.22-8.18] ms decrease
|
| GWAS snp
|
| PMID
|
[PMID 21829377]
|
| Trait
|
|
| Title
|
Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium.
|
| Risk Allele
|
T
|
| P-val
|
3E-64
|
| Odds Ratio
|
0.0200 [NR] % decrease
|
| GWAS snp
|
| PMID
|
[PMID 21886157]
|
| Trait
|
|
| Title
|
Human metabolic individuality in biomedical and pharmaceutical research.
|
| Risk Allele
|
C
|
| P-val
|
9E-116
|
| Odds Ratio
|
0.1780 None
|
[PMID 22451038] Intake levels of dietary long-chain polyunsaturated fatty acids modify the association between genetic variation in FADS and LDL cholesterol
| GWAS snp
|
| PMID
|
[PMID 22286219]
|
| Trait
|
|
| Title
|
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
| Risk Allele
|
|
| P-val
|
0
|
| Odds Ratio
|
0.5700 None
|
[PMID 19750004] A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.
[PMID 19798445] Genetic determinants of circulating sphingolipid concentrations in European populations.
[PMID 19951432] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
[PMID 20364269] A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle.
[PMID 20385826] Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
[PMID 20565855] Genetic variation in lipid desaturases and its impact on the development of human disease.
[PMID 20972250] Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.
[PMID 21347282] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
[PMID 21414826] Polymorphisms in FADS1 and FADS2 alter desaturase activity in young Caucasian and Asian adults.
[PMID 23808484] Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study.
[PMID 28359317] A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution.
[PMID 31991592] Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome.
[PMID 32397743] FADS1 Genotype Associates with Aortic Valve FADS mRNA Expression, Fatty Acid Content and Calcification.
]
