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From SNPedia

Make rs1799964(C;C)
Make rs1799964(C;T)
Make rs1799964(T;T)
ReferenceGRCh38 38.1/141
GeneLOC100287329, LTA, TNF
is asnp
is mentioned by
dbSNP (classic)rs1799964
1000 genomesrs1799964
GWAS Ctlgrs1799964
Max Magnitude0
? (C;C) (C;T) (T;T) 28

Associated with at least one "mortality outcome" in a study of ~10,000 individuals.[PMID 18263601]

Separately, a meta-analysis of 10 case-control studies, including over 2,200 Graves' disease cases, concluded that rs1799964(C) carriers were associated with the disease.[PMID 18472000]

[PMID 19818126OA-icon.png] Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study

[PMID 20887379] Tumour necrosis factor haplotypes associated with sensory neuropathy in Asian and Caucasian human immunodeficiency virus patients

[PMID 21995493OA-icon.png] TNFRSF1B +676 T>G polymorphism predicts survival of non-Small cell lung cancer patients treated with chemoradiotherapy

[PMID 22666399OA-icon.png] Tumor Necrosis Factor-α Induced Protein 8 Polymorphism and Risk of Non-Hodgkin's Lymphoma in a Chinese Population: A Case-Control Study

[PMID 12509789OA-icon.png] Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis.

[PMID 17216494] Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk.

[PMID 17493155] Significant association between TNF-alpha (TNF) promoter allele (-1031C, -863C, and -857C) and cerebral malaria in Thailand.

[PMID 18194515OA-icon.png] Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population.

[PMID 18196539] TNF polymorphisms and prostate cancer risk.

[PMID 18620570OA-icon.png] The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency.

[PMID 18635873OA-icon.png] TNF promoter polymorphisms associated with muscle phenotypes in humans.

[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18709160OA-icon.png] Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.

[PMID 18715339OA-icon.png] Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.

[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 18811622] Association of TNF-alpha with severe respiratory syncytial virus infection and bronchial asthma.

[PMID 19167443OA-icon.png] Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia.

[PMID 19281305OA-icon.png] Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.

[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19409079OA-icon.png] Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study.

[PMID 19615068OA-icon.png] The role of TNF genetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study.

[PMID 19661089OA-icon.png] Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.

[PMID 19673019OA-icon.png] IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.

[PMID 20007930OA-icon.png] A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.

[PMID 20112337OA-icon.png] Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers.

[PMID 20459604OA-icon.png] Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes.

[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 20668555OA-icon.png] Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.

[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 23472126OA-icon.png] The Association between Polymorphisms in the MRPL4 and TNF-α Genes and Susceptibility to Allergic Rhinitis

GWAS snp
PMID [PMID 21102463OA-icon.png]
Trait Crohn's disease
Title Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Risk Allele C
P-val 4E-11
Odds Ratio 1.19 [1.13-1.25]

[PMID 23840460OA-icon.png] Lymphotoxin Alpha (LTA) Polymorphism Is Associated with Prognosis of Non-Hodgkin's Lymphoma in a Chinese Population

[PMID 23870134OA-icon.png] Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma

[PMID 24003533] Relationship between cytokine single nucleotide polymorphisms and sarcoidosis among Japanese subjects

[PMID 24151497OA-icon.png] Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria

[PMID 23380141] Association of HLA-DRB1 and TNF genotypes with dengue hemorrhagic fever

[PMID 24405540] [Association of TNF-1031T/C and clinical efficacy of insulin therapy in newly diagnosed type 2 diabetics]

[PMID 22464751OA-icon.png] SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors.

[PMID 22711844] SNPs in the TNF-alpha gene promoter associated with Behcet's disease in Moroccan patients.

[PMID 22808100OA-icon.png] Functional differences exist between TNFalpha promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant.

[PMID 23071570OA-icon.png] Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level.

[PMID 23777929] Searching for an immunogenetic factor that will illuminate susceptibility to non-tuberculous mycobacterial disease.

[PMID 24935328] Functional tumor necrosis factor alpha polymorphisms and haplotype analysis in high-risk corneal transplantation

[PMID 25054016OA-icon.png] Association of NQO1 and TNF polymorphisms with Parkinson's disease: A meta-analysis of 15 genetic association studies

[PMID 25246119] Family association study between tumour necrosis factor a gene polymorphisms and polycystic ovary syndrome in Han Chinese

[PMID 25636570] Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil

[PMID 24726621OA-icon.png] Cytokine gene variations associated with subsyndromal depressive symptoms in patients with breast cancer

[PMID 25809685] Common Variants and Haplotypes in the TF, TNF-α, and TMPRSS6 Genes Are Associated with Iron Status in a Female Black South African Population

[PMID 24896147OA-icon.png] Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans

[PMID 26550110OA-icon.png] The role of gene variants of the inflammatory markers CRP and TNF-α in cardiovascular heart disease: systematic review and meta-analysis

[PMID 27477483] TNFA gene variants related to the inflammatory status and its association with cellular aging: From the CORDIOPREV study.

[PMID 28633686] Polymorphisms of the TNF-α gene interact with plasma fatty acids on inflammatory biomarker profile: a population-based, cross-sectional study in São Paulo, Brazil.

[PMID 29027627] Association of TNF-α-3959T/C Gene Polymorphisms in the Chinese Population with Intracranial Aneurysms.

[PMID 29118938OA-icon.png] Association between TNF-α rs1799964 and RAF1 rs1051208 MicroRNA binding site SNP and gastric cancer susceptibility in an Iranian population.

[PMID 31896166] Risk factors for histological progression of nonalcoholic steatohepatitis analyzed from repeated biopsy cases.

[PMID 32655394OA-icon.png] Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study.